| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
Papers In Press, published online ahead of print February 1, 2004
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226
Corresponding Author: gsonnen{at}mcw.edu
In our ongoing effort to identify genes influencing the biological pathways which underlie the metabolic disturbances associated with obesity, we performed genome-wide scanning in 2209 individuals distributed over 507 Caucasian families to localize quantitative trait loci (QTLs) that affect variation of plasma lipids. Pedigree-based analysis using a quantitative trait variance component linkage method localized a QTL on chromosome 7q35-q36 which linked to variation in levels of plasma triglyceride (TG, LOD score = 3.7) and was suggestive of linkage to LDL-cholesterol (LDL-C, LOD = 2.2). Covariates of the TG linkage included waist circumference, fasting insulin, and insulin:glucose, but not body mass index (BMI) or hip circumference. Plasma HDL-cholesterol (HDL-C) levels were suggestively linked to a second QTL on chromosome 12p12.3 (LOD = 2.6). Five other QTLs with lower LOD scores were identified for plasma levels of LDL-C, HDL-C, and total cholesterol. These newly identified loci likely harbor genetic elements that influence traits underlying lipid adversities associated with obesity.
Revised on January 8, 2004
Accepted on January 16, 2004
Genetic determinants of obesity-related lipid traits
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  K. Aberg, F. Dai, G. Sun, E. Keighley, S. R. Indugula, L. Bausserman, S. Viali, J. Tuitele, R. Deka, D. E. Weeks, et al. A genome-wide linkage scan identifies multiple chromosomal regions influencing serum lipid levels in the population on the Samoan islands J. Lipid Res., October 1, 2008; 49(10): 2169 - 2178. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Malhotra, S. C. Elbein, M. C.Y. Ng, R. Duggirala, R. Arya, G. Imperatore, A. Adeyemo, T. I. Pollin, W.-C. Hsueh, J. C.N. Chan, et al. Meta-Analysis of Genome-Wide Linkage Studies of Quantitative Lipid Traits in Families Ascertained for Type 2 Diabetes Diabetes, March 1, 2007; 56(3): 890 - 896. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Zhou, C. M. Evock-Clover, J. P. McMurtry, C. M. Ashwell, and S. J. Lamont Genome-Wide Linkage Analysis to Identify Chromosomal Regions Affecting Phenotypic Traits in the Chicken. IV. Metabolic Traits Poult. Sci., February 1, 2007; 86(2): 267 - 276. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Wittenburg, M. A. Lyons, R. Li, U. Kurtz, X. Wang, J. Mossner, G. A. Churchill, M. C. Carey, and B. Paigen QTL mapping for genetic determinants of lipoprotein cholesterol levels in combined crosses of inbred mouse strains, J. Lipid Res., August 1, 2006; 47(8): 1780 - 1790. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Yu, D. F. Wyszynski, D. M. Waterworth, S. D. Wilton, P. J. Barter, Y. A. Kesaniemi, R. W. Mahley, R. McPherson, G. Waeber, T. P. Bersot, et al. Multiple QTLs influencing triglyceride and HDL and total cholesterol levels identified in families with atherogenic dyslipidemia J. Lipid Res., October 1, 2005; 46(10): 2202 - 2213. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W.-D. Li, C. Dong, D. Li, C. Garrigan, and R. A. Price A genome scan for serum triglyceride in obese nuclear families J. Lipid Res., March 1, 2005; 46(3): 432 - 438. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Wang and B. Paigen Genetics of Variation in HDL Cholesterol in Humans and Mice Circ. Res., January 7, 2005; 96(1): 27 - 42. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| All ASBMB Journals | Journal of Biological Chemistry |
| Molecular and Cellular Proteomics | ASBMB Today |
