Submitted on November 24, 2003
Revised on February 12, 2004
Accepted on February 12, 2004
Triglyceride levels are ethnic-specifically associated with the ratio of plasma oleic acid to stearic acid as an index of stearoyl-CoA desaturase activity and n-3 PUFA levels in Northeast Asians
Kuninori Shiwaku, Michio Hashimoto, Keiko Kitajima, Akiko Nogi, Erdembileg Anuurad, Byambaa Enkhmaa, Jung-Man Kim, In-Shik Kim, Sung-Kook Lee, Tsendsuren Oyunsuren, Osamu Shido, and Yosuke Yamane
Environmental & Preventive Medicine, Shimane University School of Medicine, Izumo, Shimane 693-8601
Corresponding Author: shiwaku{at}med.shimane-u.ac.jp
Accumulated evidence suggests that hypertriglyceridemia (HTG) is independently associated with an increased incidence of cardiovascular disease. The hypotriglyceridemic effects of n-3 PUFA has been confirmed in Caucasians, but the effect in Asians is less clear. Recent evidence indicates that stearoyl-CoA desaturase (SCD) activity induced with high carbohydrate diets increases plasma triglyceride levels. We investigate the relationship between triglyceride levels and the ratio of plasma oleic acid to stearic acid (the 18:1/18:0 ratio), a plasma marker of SCD activity and n-3 PUFA in a total of 411 Japanese, 418 Korean and 251 Mongolian adults. The Japanese and Koreans had higher values for triglyceride than their Mongolian counterparts, despite lower BMI values for the Japanese and Koreans. The Japanese and Koreans ate fish more frequently and had remarkable higher values for n-3 PUFA than did the Mongolians. Multiple regression analysis showed that triglyceride levels had a great magnitude of correlation with increases in the 18:1/18:0 ratio for the Japanese and Mongolians, and n-3 PUFA remained significant for the Mongolians. HTG is ethnic-specifically associated with an increase in the 18:1/18:0 ratio or a decrease in n-3 PUFA in plasma for the Japanese, Koreans and Mongolians.
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