J. Lipid Res. Please sign the JLR Guestbook
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

A more recent version of this article appeared on June 1, 2004

Papers In Press, published online ahead of print April 1, 2004
J. Lipid Res., doi:10.1194/jlr.M300526-JLR200
This Article
Right arrow Full Text (Accepted Manuscript)
Right arrow All Versions of this Article:
M300526-JLR200v1
45/6/1112    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Song, C.
Right arrow Articles by Horrobin, D. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Song, C.
Right arrow Articles by Horrobin, D. F.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Submitted on December 24, 2003
Revised on March 18, 2004
Accepted on March 19, 2004

Omega-3 fatty acid ethyl-eicosapentaenoate but not soybean oil attenuates memory impairment induced by central IL-1beta administration

Cai Song and David F. Horrobin

Psychiatry Dept., University of British Columbia, Vancouver, British Columbia V6T 2A1

Corresponding Author: caisong{at}interchange.ubc.ca

Pro-inflammatory cytokine interleukin-1beta (IL-1) can cause cognitive impairment, activate the hypothalamic-pituitary-adrenal axis and impair monoaminergic neurotransmission in the rat. IL-1 has also been shown to increase the concentration of the inflammatory mediator prostaglandin (PG)E2 in the blood. Omega (n)-3 fatty acids such as eicosapentaenoic acid (EPA), which are components of fish oil, have been shown to reduce both the pro-inflammatory cytokines and the synthesis of PGE2. The purpose of this study was to determine whether dietary supplements of EPA would attenuate the inflammation induced impairment of spatial memory by centrally administered IL-1. Rats were fed with a diet of coconut oil (contained a negligible quantity of fatty acids), soybean oil (contained mainly n-6 fatty acids) or a diet of coconut oil enriched with ethyl-EPA. The rats were then injected intracerebroventricularly with IL-1 or saline. The results of this study demonstrated that the IL-1-induced deficit in spatial memory was correlated with an impairment of central noradrenergic and serotonergic (but not dopaminergic) function and an increase in the serum corticosterone concentration. IL-1 also caused an increase in the hippocampal PGE2 concentration. These effects of IL-1 were attenuated by the chronic administration of ethyl-EPA. By contrast, rats fed with the soybean oil diet showed no effect on the changes induced by the IL-1 administration.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Am. J. Clin. Nutr.Home page
C. Samieri, C. Feart, L. Letenneur, J.-F. Dartigues, K. Peres, S. Auriacombe, E. Peuchant, C. Delcourt, and P. Barberger-Gateau
Low plasma eicosapentaenoic acid and depressive symptomatology are independent predictors of dementia risk
Am. J. Clinical Nutrition, September 1, 2008; 88(3): 714 - 721.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
C. Song, M. S. Manku, and D. F. Horrobin
Long-Chain Polyunsaturated Fatty Acids Modulate Interleukin-1{beta}-Induced Changes in Behavior, Monoaminergic Neurotransmitters, and Brain Inflammation in Rats
J. Nutr., May 1, 2008; 138(5): 954 - 963.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
 All ASBMB Journals   Journal of Biological Chemistry 
 Molecular and Cellular Proteomics   ASBMB Today 
Copyright © 2004 by the American Society for Biochemistry and Molecular Biology.