J. Lipid Res.
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A more recent version of this article appeared on June 1, 2004

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J. Lipid Res., doi:10.1194/jlr.M400016-JLR200
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Submitted on January 16, 2004
Revised on March 2, 2004
Accepted on March 17, 2004

The S447X polymorphism at the lipoprotein lipase locus interacts with apolipoprotein E polymorphisms, smoking and alcohol consumption to determine HDL-cholesterol

Jeannette Lee, Chuen Seng Tan, Kee Seng Chia, Chee Eng Tan, Suok Kai Chew, Jose M. Ordovas, and E Shyong Tai

Department of Endocrinology, Singapore General Hospital, Singapore 169608

Corresponding Author: eshyong{at}pacific.net.sg

We studied 4058 subjects from a representative sample of the Singapore population to determine 1) the association between the S447X polymorphism at the lipoprotein lipase (LPL) locus and serum lipid concentration in Chinese, Malays and Asian Indians living in Singapore and 2) to explore any interactions with apolipoprotein E (APOE) genotype, exercise, obesity, cigarette smoking and alcohol intake. Information on obesity, lifestyle factors (including smoking, alcohol consumption and exercise frequency), glucose tolerance and fasting lipids were obtained. Male and female carriers of the X447 allele had lower serum triglyceride concentration and higher HDL cholesterol (HDL-C) concentration. The association between the X447 allele and serum HDL-C concentration was modulated by APOE genotype in males and cigarette smoking and alcohol intake in females. The effect of the X447 allele was greatest in men who carried the E4 allele and women who smoked or consumed alcohol. The X447 allele at the LPL locus is common, and associated with a less atherogenic lipid profile in Asian populations. Interactions with APOE genotype, cigarette smoking and alcohol intake reinforce the importance of examining genetic associations, such as this one, in the context of the population of interest.


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