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Papers In Press, published online ahead of print June 1, 2004
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LMBB, NIAAA, NIH, Rockville, MD 20852
Corresponding Author: nsalem{at}niaaa.nih.gov
Rat pups born to dams fed a diet with 3.1 % of total fatty acids as alpha-linolenic acid (LNA) were fed using an artificial rearing system either an n-3 deficient (n-3 Def) or n-3 adequate (n-3 Adq) diet. Both diets diet contained 17.1 % linoleic acid but the n-3 Adq diet also contained 3.1% LNA. The percentage of brain docosahexaenoic acid (DHA) continuously decreased (71%) with time over the 29 days of the experiment with concomitant increases in docosapentaenoic acid (DPAn-6). In the retina, the percentage of DHA rose in the n-3 Adq group with an apparent increased rate around the time of eye opening. However, there was a flat curve for the percentage of DHA in the n-3 Def group and a rising DPAn-6 with time. Liver DHA was highest at the time of birth in the n-3 Adq group but fell off somewhat over the course of 29 days. This decrease was more pronounced in the n-3 Def group and the DPAn-6 rose considerably during the second half of the experiment. This method presents a first generation model for n-3 deficiency that is more similar to the case of human nutrition than the commonly employed two generation model.
Revised on May 20, 2004
Accepted on May 20, 2004
Effects of an n-3 deficient diet on brain, retina and liver fatty acyl composition in artifically reared rats
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