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Papers In Press, published online ahead of print October 16, 2004
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Wallenberg Laboratory for Cardiovascular Research, Göteborg 41345
Corresponding Author: jan.boren{at}wlab.gu.se
The use of stable isotopes in conjunction with compartmental modeling analysis has greatly facilitated studies of the metabolism of the apoB-containing lipoproteins in humans. The aim of this study was to develop a multicompartment model that allows to simultaneously determine the kinetics of apoB and TG in VLDL1 and VLDL2 after a bolus injection of 2H3-leucine and 2H5-glycerol, and to follow the catabolism and transfer of the lipoprotein particles. Here, we describe the model and present the results of its application in a fasting steady-state situation in 17 subjects with lipid values representative of a Western population. Analysis of the correlations showed that plasma TG was determined by the VLDL1 and VLDL2 apoB and TG FCR. Furthermore, the model showed a linear correlation between VLDL1 TG and apoB production. A novel observation was that VLDL-TG entered the circulation within 21 min after its synthesis, whereas VLDL-apoB entered the circulation after 33 min. These observations are consistent with a sequential assembly model of VLDL and may suggest that the TG is added to a primordial apoB-containing particle in the liver.
Revised on September 30, 2004
Accepted on October 5, 2004
A new combined multicompartmental model for apolipoprotein B100 and triglyceride metabolism in VLDL subfractions
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