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Papers In Press, published online ahead of print November 16, 2004
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Lipid Research Center, CHUQ, pavilion CHUL, Quebec, Quebec G1V 4G2
Corresponding Author: marie-therese.berthier{at}crchul.ulaval.ca
Low levels of adiponectin are associated with the presence of insulin resistance and abdominal obesity. The aim of this study was first to examine the relationships between adiponectin gene (Apm1) polymorphisms and anthropometric indices as well as plasma adiponectin and lipoprotein/lipid levels, and then to investigate whether the presence of visceral obesity or insulin resistance may modulate the impact of these polymorphisms on metabolic risk variables. Molecular screening of the Apm1 gene was achieved in 5 men characterized by low visceral adipose tissue area (AT) (<130 cm2) and 19 men with high visceral AT accumulation assessed by computed tomography (>130 cm2). When a polymorphism was identified, a sample of 270 unrelated men recruited from the greater Quebec city area and selected to cover a wide range of body fatness values was genotyped. Sequencing of Apm1 gene revealed two previously reported polymorphisms (c.45T>G and c.276G>T) as well as two newly identified genetic variations (-13752delT and -13702G>C). Carriers of the c.276T allele had higher LDL-cholesterol and lower HDL-triglyceride concentrations than 276G/G homozygotes (p=0.02 and p=0.01, respectively). Carriers of the c.45G allele exhibited higher plasma adiponectin concentrations than 45T/T homozygotes (p=0.04). After dividing each genotype group into subgroups for visceral AT, homozygotes for normal allele at position –13752delT, carriers of c.45G allele or carriers of c.276T allele had similar total apoB concentrations although they were viscerally obese or not. After classifying each genotype group into subgroups using 80 pmol/l as a cutoff point for fasting insulin, carriers of the –13752delT carriers with hyperinsulinemia had lower adiponectin concentrations compared to their counterparts with normal fasting insulin levels (p<0.05). These results suggest that some Apm1 gene polymorphisms influence plasma adiponectin concentrations and lipoprotein/lipid levels. In addition, the impact of these polymorphisms is modulated by the presence of visceral obesity and insulin resistance.
Revised on November 1, 2004
Accepted on November 4, 2004
Impact of adiponectin gene polymorphismson plasma lipoprotein and adiponectin concentrations of viscerally obese men
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