| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
Papers In Press, published online ahead of print July 16, 2004
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Department of Molecular Medicine, National Public Health Institute, Helsinki, Helsinki 00251
Corresponding Author: leena.peltonen{at}ktl.fi
Decreased HDL-cholesterol (HDL-C) and familial combined hyperlipidemia (FCHL) are the two most common familial dyslipidemias predisposing to premature coronary heart disease (CHD). These dyslipidemias share many phenotypic features, suggesting a partially overlapping molecular pathogenesis. This was supported by our previous pooled data analysis of the genome scans for low HDL-C and FCHL, which identified three shared chromosomal regions for a qualitative HDL-C trait on 8q23.1, 16q23.3, and 20q13.32. This study further investigates these regions as well as two other loci we identified earlier for premature CHD on 2q31 and Xq24, and a locus for high serum triglycerides (TGs) on 10q11. We analyzed 67 microsatellite markers in an extended study sample of 1109 individuals from 92 low HDL-C or FCHL families using both qualitative and quantitative lipid phenotypes. These analyses provided evidence for linkage (a lod score of 3.2) on 10q11 using a quantitative HDL-C trait. Importantly, this region, previously linked to TGs, BMI and obesity, provided evidence for association for both quantitative HDL-C and TGs with marker D10S546 (p-value 0.0006). Suggestive evidence for linkage also emerged for HDL-C on 2q31 and for TGs on 20q13.32. Finnish families ascertained for dyslipidemias would thus imply that 10q11, 2q31 and 20q13.32 harbour loci for HDL-C and TGs.
Revised on July 7, 2004
Accepted on July 9, 2004
Locus for quantitative HDL-cholesterol on chromosome 10q in Finnish families with dyslipidemia
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  R. Mar-Heyming, M. Miyazaki, D. Weissglas-Volkov, N. A. Kolaitis, N. Sadaat, C. Plaisier, P. Pajukanta, R. M. Cantor, T. W.A. de Bruin, J. M. Ntambi, et al. Association of Stearoyl-CoA Desaturase 1 Activity With Familial Combined Hyperlipidemia Arterioscler. Thromb. Vasc. Biol., June 1, 2008; 28(6): 1193 - 1199. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. K. Arnett, A. E. Baird, R. A. Barkley, C. T. Basson, E. Boerwinkle, S. K. Ganesh, D. M. Herrington, Y. Hong, C. Jaquish, D. A. McDermott, et al. Relevance of Genetics and Genomics for Prevention and Treatment of Cardiovascular Disease: A Scientific Statement From the American Heart Association Council on Epidemiology and Prevention, the Stroke Council, and the Functional Genomics and Translational Biology Interdisciplinary Working Group Circulation, June 5, 2007; 115(22): 2878 - 2901. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Wittenburg, M. A. Lyons, R. Li, U. Kurtz, X. Wang, J. Mossner, G. A. Churchill, M. C. Carey, and B. Paigen QTL mapping for genetic determinants of lipoprotein cholesterol levels in combined crosses of inbred mouse strains, J. Lipid Res., August 1, 2006; 47(8): 1780 - 1790. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Weissglas-Volkov, A. Huertas-Vazquez, E. Suviolahti, J. Lee, C. Plaisier, S. Canizales-Quinteros, T. Tusie-Luna, C. Aguilar-Salinas, M.-R. Taskinen, and P. Pajukanta Common Hepatic Nuclear Factor-4{alpha} Variants Are Associated With High Serum Lipid Levels and the Metabolic Syndrome. Diabetes, July 1, 2006; 55(7): 1970 - 1977. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Suviolahti, K. Reue, R. M. Cantor, J. Phan, M. Gentile, J. Naukkarinen, A. Soro-Paavonen, L. Oksanen, J. Kaprio, A. Rissanen, et al. Cross-species analyses implicate Lipin 1 involvement in human glucose metabolism Hum. Mol. Genet., February 1, 2006; 15(3): 377 - 386. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Dastani, L. Quiogue, C. Plaisier, J. C. Engert, M. Marcil, J. Genest, and P. Pajukanta Evidence for a Gene Influencing High-Density Lipoprotein Cholesterol on Chromosome 4q31.21 Arterioscler. Thromb. Vasc. Biol., February 1, 2006; 26(2): 392 - 397. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Yu, D. F. Wyszynski, D. M. Waterworth, S. D. Wilton, P. J. Barter, Y. A. Kesaniemi, R. W. Mahley, R. McPherson, G. Waeber, T. P. Bersot, et al. Multiple QTLs influencing triglyceride and HDL and total cholesterol levels identified in families with atherogenic dyslipidemia J. Lipid Res., October 1, 2005; 46(10): 2202 - 2213. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Pollex and R. A. Hegele Complex Trait Locus Linkage Mapping in Atherosclerosis: Time to Take a Step Back Before Moving Forward? Arterioscler. Thromb. Vasc. Biol., August 1, 2005; 25(8): 1541 - 1544. [Full Text] [PDF]
|
|
|
|
 |
|
 X. Wang and B. Paigen Genetics of Variation in HDL Cholesterol in Humans and Mice Circ. Res., January 7, 2005; 96(1): 27 - 42. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| All ASBMB Journals | Journal of Biological Chemistry |
| Molecular and Cellular Proteomics | ASBMB Today |
