Submitted on April 19, 2004
Revised on August 30, 2004
Accepted on September 23, 2004
Apolipoprotein E gene polymorphisms and thrombosis and restenosis after coronary artery stenting
Werner Koch, Julinda Mehilli, Arne Pfeufer, Albert Schömig, and Adnan Kastrati
Deutsches Herzzentrum München, München 80636
Corresponding Author: wkoch{at}dhm.mhn.de
Experimental data support a protective function of apolipoprotein E (apoE) against restenosis, the main factor limiting the long-term benefit of percutaneous coronary interventions. We investigated the possibility that the single nucleotide polymorphisms –219G/T, 113G/C, 334T/C, and 472C/T of the gene encoding apoE (APOE) are associated with the incidence of death and myocardial infarction or restenosis after stenting in coronary arteries. In addition, we asked whether the apoE isotype-related 
2/3/4 polymorphism, defined by specific allele combinations (haplotypes) of the 334T/C and 472C/T polymorphism, and other APOE haplotypes, derived from all investigated 4 single nucleotide polymorphisms, are associated with adverse clinical and angiographic outcomes after stenting. Our study included 1,850 consecutive patients with symptomatic coronary artery disease who underwent stent implantation. Follow-up angiography was performed in 1,556 patients (84.1%) at 6 months after the intervention. We found that none of the APOE single nucleotide polymorphisms is associated with death and myocardial infarction or restenosis after stenting. In addition, we did not observe any relationship between APOE haplotypes and adverse outcomes. In conclusion, the APOE –219G/T, 113G/C, 334T/C, and 472C/T polymorphism, either alone or in combination, do not represent genetic markers of the risk of thrombotic and restenotic complications in patients with coronary artery disease treated with coronary stenting.
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