| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
Papers In Press, published online ahead of print September 1, 2004
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Nutrition & Genomics, Tufts University, Boston, MA 02111
Corresponding Author: jose.ordovas{at}tufts.edu
Several polymorphisms in the APOA5 gene have been associated with increased plasma triglyceride (TG) concentrations. However, associations between APOA5 and lipoprotein subclasses, remnant-like particles (RLP), and cardiovascular disease (CVD) risk have been less explored. We investigated associations of five APOA5 SNPs (–1131T>C, –3A>G, 56C>G IVS3+476G>A and 1259T>C) with lipoprotein subfractions and CVD risk in 1129 men and 1262 women participating in the Framingham Heart Study. Except for the 56C>G, the other SNPs were in significant linkage disequilibrium, resulting in three haplotypes (11111, 22122, and 11211) representing 98% of the population. SNP analyses revealed that the –1131T>C and 56C>G SNPs were significantly associated with higher plasma TG concentrations in both men and women. For RLP and lipoprotein subclasses we observed gender-specific association for the –1131T>C and 56C>G SNPs. Female carriers of the -1131C allele had higher RLP concentrations, whereas in males, significant associations for RLP were observed for the 56G allele. Moreover, haplotype analyses confirmed these findings and revealed that the 22122 and 11211 haplotypes exhibited different associations with HDL-C concentrations. In women, the -1131C allele was associated with a higher hazard ratio for CVD (HR: 1.85;CI95% 1.03-3.34, p=0.04) in agreement with the association of this SNP with higher RLP.
Revised on August 19, 2004
Accepted on August 20, 2004
Influence of the APOA5 locus on plasma triglyceride, remnant-like particles, lipoprotein subclasses and cardiovascular disease risk in the framingham heart study
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  E. Olano-Martin, E. C. Abraham, R. Gill-Garrison, A. M. Valdes, K. Grimaldi, F. Tang, K. G. Jackson, C. M. Williams, and A. M. Minihane Influence of apoA-V gene variants on postprandial triglyceride metabolism: impact of gender J. Lipid Res., May 1, 2008; 49(5): 945 - 953. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Grallert, E.-M. Sedlmeier, C. Huth, M. Kolz, I. M. Heid, C. Meisinger, C. Herder, K. Strassburger, A. Gehringer, M. Haak, et al. APOA5 variants and metabolic syndrome in Caucasians J. Lipid Res., December 1, 2007; 48(12): 2614 - 2621. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Sundl, M. Guardiola, G. Khoschsorur, R. Sola, J. C. Vallve, G. Godas, L. Masana, M. Maritschnegg, A. Meinitzer, N. Cardinault, et al. Increased concentrations of circulating vitamin E in carriers of the apolipoprotein A5 gene 1131T>C variant and associations with plasma lipids and lipid peroxidation J. Lipid Res., November 1, 2007; 48(11): 2506 - 2513. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Moreno-Luna, F. Perez-Jimenez, C. Marin, P. Perez-Martinez, P. Gomez, Y. Jimenez-Gomez, J. Delgado-Lista, J. A. Moreno, T. Tanaka, J. M. Ordovas, et al. Two Independent Apolipoprotein A5 Haplotypes Modulate Postprandial Lipoprotein Metabolism in a Healthy Caucasian Population J. Clin. Endocrinol. Metab., June 1, 2007; 92(6): 2280 - 2285. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-Q. Lai, D. K. Arnett, D. Corella, R. J. Straka, M. Y. Tsai, J. M. Peacock, X. Adiconis, L. D. Parnell, J. E. Hixson, M. A. Province, et al. Fenofibrate Effect on Triglyceride and Postprandial Response of Apolipoprotein A5 Variants: The GOLDN Study Arterioscler. Thromb. Vasc. Biol., June 1, 2007; 27(6): 1417 - 1425. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Sarwar, J. Danesh, G. Eiriksdottir, G. Sigurdsson, N. Wareham, S. Bingham, S. M. Boekholdt, K.-T. Khaw, and V. Gudnason Triglycerides and the Risk of Coronary Heart Disease: 10 158 Incident Cases Among 262 525 Participants in 29 Western Prospective Studies Circulation, January 30, 2007; 115(4): 450 - 458. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. F. C. Vaessen, F. G. Schaap, J.-A. Kuivenhoven, A. K. Groen, B. A. Hutten, S. M. Boekholdt, H. Hattori, M. S. Sandhu, S. A. Bingham, R. Luben, et al. Apolipoprotein A-V, triglycerides and risk of coronary artery disease: the prospective Epic-Norfolk Population Study J. Lipid Res., September 1, 2006; 47(9): 2064 - 2070. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-Q. Lai, D. Corella, S. Demissie, L. A. Cupples, X. Adiconis, Y. Zhu, L. D. Parnell, K. L. Tucker, and J. M. Ordovas Dietary Intake of n-6 Fatty Acids Modulates Effect of Apolipoprotein A5 Gene on Plasma Fasting Triglycerides, Remnant Lipoprotein Concentrations, and Lipoprotein Particle Size: The Framingham Heart Study Circulation, May 2, 2006; 113(17): 2062 - 2070. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Elosua, J. M. Ordovas, L. A. Cupples, C.-Q. Lai, S. Demissie, C. S. Fox, J. F. Polak, P. A. Wolf, R. B. D'Agostino Sr., and C. J. O'Donnell Variants at the APOA5 locus, association with carotid atherosclerosis, and modification by obesity: the Framingham Study J. Lipid Res., May 1, 2006; 47(5): 990 - 996. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Hodoglugil, S. Tanyolac, D. W. Williamson, Y. Huang, and R. W. Mahley Apolipoprotein A-V: a potential modulator of plasma triglyceride levels in Turks J. Lipid Res., January 1, 2006; 47(1): 144 - 153. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. Ruiz-Narvaez, Y. Yang, Y. Nakanishi, J. Kirchdorfer, and H. Campos APOC3/A5 haplotypes, lipid levels, and risk of myocardial infarction in the Central Valley of Costa Rica J. Lipid Res., December 1, 2005; 46(12): 2605 - 2613. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ishihara, T. Kujiraoka, T. Iwasaki, M. Nagano, M. Takano, J. Ishii, M. Tsuji, H. Ide, I. P. Miller, N. E. Miller, et al. A sandwich enzyme-linked immunosorbent assay for human plasma apolipoprotein A-V concentration J. Lipid Res., September 1, 2005; 46(9): 2015 - 2022. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Prieur, T. Huby, H. Coste, F. G. Schaap, M. J. Chapman, and J. C. Rodriguez Thyroid Hormone Regulates the Hypotriglyceridemic Gene APOA5 J. Biol. Chem., July 29, 2005; 280(30): 27533 - 27543. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Frances, D. Corella, J. V. Sorli, M. Guillen, J. I. Gonzalez, and O. Portoles Validating a Rapid Method for Detecting Common Polymorphisms in the APOA5 Gene by Melting Curve Analysis Using LightTyper Clin. Chem., July 1, 2005; 51(7): 1279 - 1282. [Full Text] [PDF]
|
|
|
|
|
|
M. Merkel, B. Loeffler, M. Kluger, N. Fabig, G. Geppert, L. A. Pennacchio, A. Laatsch, and J. Heeren Apolipoprotein AV Accelerates Plasma Hydrolysis of Triglyceriderich Lipoproteins by Interaction with Proteoglycan-bound Lipoprotein Lipase J. Biol. Chem., June 3, 2005; 280(22): 21553 - 21560. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. L. E. Klos, S. Hamon, A. G. Clark, E. Boerwinkle, K. Liu, and C. F. Sing APOA5 polymorphisms influence plasma triglycerides in young, healthy African Americans and whites of the CARDIA Study J. Lipid Res., March 1, 2005; 46(3): 564 - 571. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| All ASBMB Journals | Journal of Biological Chemistry |
| Molecular and Cellular Proteomics | ASBMB Today |
