J. Lipid Res. Neurobiology of Lipids (ISSN1683-5506)
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A more recent version of this article appeared on November 1, 2004

Papers In Press, published online ahead of print August 1, 2004
J. Lipid Res., doi:10.1194/jlr.M400202-JLR200
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Submitted on May 27, 2004
Revised on July 28, 2004
Accepted on July 30, 2004

Genetic variants of the lipoprotein lipase gene in myocardial infarction in the central valley of costa rica

Yadong Yang, Edward Ruiz-Narvaez, Tianhua Niu, Xiping Xu, and Hannia Campos

Nutrition, Harvard School of Public Health, Boston, MA 02115

Corresponding Author: hcampos{at}hsph.harvard.edu

Objective: To assess common variants of the lipoprotein lipase (LPL) gene that could influence susceptibility to myocardial infarction (MI). Methods and Results: Three functional SNPs, D9N, N291S and S447X were examined in 1,321 survivors of a first acute MI and 1,321 population-based controls, matched for age, gender and area of residence, all living in the Central Valley of Costa Rica. Conditional logistic regression was used to estimate odds ratio (OR) and 95% confidence interval (CI). The frequency of the X447 mutant allele was significantly lower in cases than controls (6.2% vs. 7.6%, p<0.01), whereas no association with MI was found for D9N or N291S. Carriers of the X447 allele had lower risk of MI compared to non-carriers, OR=0.80 (95% CI, 0.63-1.01). When a haplotype containing the X447 mutant and the D9N and N291S normal alleles was compared to the triple normal haplotype, the OR was 0.66 (95% CI, 0.48-0.91). Four other functional mutants and eight neutral SNPs were evaluated in a subgroup of the population, but they were either monomorphic or had no association with MI. Conclusions: The X447 mutant allele of the LPL gene may confer protection from MI in the Costa Rican population.


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