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J. Lipid Res.
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A more recent version of this article appeared on December 1, 2004

Papers In Press, published online ahead of print September 1, 2004
J. Lipid Res., doi:10.1194/jlr.M400250-JLR200
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Submitted on July 1, 2004
Revised on August 30, 2004
Accepted on August 30, 2004

Measurement of the active and low-active forms of phospholipid transfer protein in a Finnish population sample: correlations with lipids and lipoproteins

Minna T. Jänis, Sarah Siggins, Esa Tahvanainen, Riikka Vikstedt, Kaisa Silander, Jari Metso, Arpo Aromaa, Marja-Riitta Taskinen, Vesa M. Olkkonen, Matti Jauhiainen, and Christian Ehnholm

Department of Molecular Medicine, National Public Health Institute, Helsinki, Helsinki FIN-00251

Corresponding Author: minna.janis{at}ktl.fi

Human serum phospholipid transfer protein (PLTP) exists as a catalytically active (HA-PLTP) and a low-active (LA-PLTP) form. In this study, association of PLTP activity and the concentrations of both forms with lipid and carbohydrate parameters were investigated. In a random Finnish population sample serum PLTP concentration (n=250) was 6.56 +\- 1.45 mg/l, the mean lipoprotein-independent (PLTPexo) phospholipid transfer activity was 6.59 +\- 1.66 µmol/ml/h, and the mean lipoprotein-dependent (PLTPendo) activity was 1.37 +\- 0.29 µmol/ml/h. Of the serum PLTP concentration, approximately 46% was in a catalytically active form. HA-PLTP concentration correlated positively with serum PLTPexo activity (r=0.380, p<0.001), HDL cholesterol (r=0.291, p<0.001) and apolipoprotein A-I (r=0.187, p<0.01). Of the potential regulatory factors for PLTP, apolipoprotein E showed a weak positive correlation with serum PLTPexo (r=0.154, p<0.05) and PLTPendo (r=0.192, p<0.01) activity but not with PLTP concentration. Weak associations were also observed between PLTP parameters and determinants of glucose homeostasis (glucose, insulin, and homeostasis model assessment for insulin resistance). The present data on PLTP activity and concentration reveal novel connections of the two PLTP forms to lipid and carbohydrate metabolism.


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