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Papers In Press, published online ahead of print December 16, 2004
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Laboratorio de Investigación, Carlos Haya Hospital, Málaga, Málaga 29009
Corresponding Author: lourgarrido{at}hotmail.com
Abstract Most studies of antibodies to oxidized LDL have been undertaken in patients with different diseases and cardiovascular risk factors. However, very few studies have researched the distribution and determining factors of antibodies to oxidized LDL in the general population. A total of 1354 persons (817 female and 537 male) aged 5-65 years were included in the study. They were selected randomly from the population census of Malaga, in southern Spain. The females had lower levels of total cholesterol and triglycerides and higher levels of HDL cholesterol and a very significant increase (P<0.0001) in levels of anti-oxidized LDL (MDA-LDL) antibodies, but no difference in levels of immune complexes consisting of LDL and IgG antibodies (anti-LDL immune complex). Younger persons (16-35 years) had higher levels of anti-oxidized LDL (MDA-LDL) antibodies than persons over 35 years of age (P=0.05). Levels of immune complexes were significantly higher (P=0.05) in persons aged 5-15 years than persons over 40 years of age. A very weak association was found between levels of anti-oxidized LDL (MDA-LDL) antibodies and anti-LDL immune complexes. The higher prevalence of anti-oxidized LDL (MDA-LDL) antibodies in females and young persons is in line with those who have found an inverse association between atherosclerosis and the level of these antibodies.
Revised on December 8, 2004
Accepted on December 11, 2004
Influence of age and sex on levels on anti-oxidized LDL antibodies and anti-oxidized LDL immune complexes in the general population
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