Polymorphisms of intestinal fatty acid binding protein and microsomal triglyceride transfer protein genes in french canadian youth

Simona Stan, Marie Lambert, Edgard Delvin, Gilles Paradis, Jennifer O'Loughlin, James Hanley, and Emile Levy

Nutrition, Hôpital Ste-Justine, Montréal, Québec H3T 1C5

Corresponding Author: emile.levy{at}recherche-ste-justine.qc.ca

Growing evidence suggests an association between lipid abnormalities and each of fatty acid binding protein (FABP), and microsomal triglyceride transfer protein (MTP) gene variants. Our objectives were to determine whether the Ala54Thr FABP2 and G-493T MTP gene polymorphisms (i) are associated with an increased risk of the insulin resistance syndrome (IRS) in youth and/or (ii) modify the expression of dyslipidemia associated with IRS. We studied 1742 French Canadians aged 9, 13 and 16 years who took part into the 1999 Quebec Child and Adolescent Health and Social Survey. This study did not provide evidence on a potential predisposition to IRS related to either FABP2 or MTP genotypes (OR = 0.57-1.05, p< 0.05). However, we observed a heterogeneity of FABP2 effect by IRS status on total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C) and apolipoprotein (apo) B concentrations (p for interaction = 0.045, 0.018, and 0.017, respectively). Among the metabolic components of IRS, only TG displayed an interaction with FABP2 polymorphism: compared to Thr/Ala and Ala/Ala, the Thr/Thr genotype was associated with a steeper increase in TC, LDL-C and apo B parallel to TG concentrations (p < 0.001 for TC, LDL-C and apo B). IRS did not modify the associations between MTP polymorphism and any of TC, LDL-C, apo B, high-density lipoprotein cholesterol (HDL-C), apo A-I, TG, free fatty acids (FFA), glucose, and insulin (all p > 0.05). Our study suggests that the effects of allelic variations of FABP2 on lipid traits are context dependent, indicating that this variant may play an important role in the pathogenesis of cardiovascular disease in presence of IRS or hypertriglyceridemia.

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