J. Lipid Res. Neurobiology of Lipids (ISSN1683-5506)
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

A more recent version of this article appeared on April 1, 2005

Papers In Press, published online ahead of print January 16, 2005
J. Lipid Res., doi:10.1194/jlr.M400392-JLR200
This Article
Right arrow Full Text (Accepted Manuscript)
Right arrow All Versions of this Article:
M400392-JLR200v1
46/4/736    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Martinez, B.
Right arrow Articles by Santos, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Martinez, B.
Right arrow Articles by Santos, A.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Submitted on October 7, 2004
Revised on December 21, 2004
Accepted on January 10, 2005

The mitochondrial respiratory complex I is a target for 15 deoxy-delta-12,14-PGJ2 (15d-PGJ2) action

B. Martinez, A. Perez-Castillo, and A. Santos

Facultad de Medicina, Universidad Complutense, Madrid 28040

Corresponding Author: piedras3{at}med.ucm.es

The prostaglandin J2 derivate 15 deoxy-delta-12,14-PGJ2 (15d-PGJ2) is a very active compound with important effects on inflammation, apoptosis, and cell growth processes. To exert this broad range of effects, 15d-PGJ2 binds and alters the activity of diverse proteins, which consequently are postulated to be mediators of its action. Among them are the transcription factors PPARgamma and NF-kB, thought to play an essential role in the anti-tumorigenic and anti-inflammatory actions of 15d-PGJ2. Here, we show that 15d-PGJ2, at micromolar concentrations, efficiently blocks state 3 oxygen consumption in intact non-synaptic mitochondria isolated from rat cerebral cortex. This effect is due to the inhibition by this prostaglandin of the activity of the enzyme NADH-ubiquinone reductase (complex I) of the mitochondrial respiratory chain. In addition to this, 15d-PGJ2 dramatically increases the rate of ROS generation by complex I. The inhibition by 15d-PGJ2 of complex I activity was abolished by dithiothreitol, which rises the possibility that adduct formation with a critical component of complex I accounts for the inhibitory effect of this prostaglandin. These results clearly identify mitochondrial complex I as a new target for 15d-PGJ2 actions.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 CarcinogenesisHome page
E.-H. Kim, H.-K. Na, D.-H. Kim, S.-A. Park, H.-N. Kim, N.-Y. Song, and Y.-J. Surh
15-Deoxy-{Delta}12,14-prostaglandin J2 induces COX-2 expression through Akt-driven AP-1 activation in human breast cancer cells: a potential role of ROS
Carcinogenesis, April 1, 2008; 29(4): 688 - 695.
[Abstract] [Full Text] [PDF]

Home page
 Annals of Clinical & Laboratory ScienceHome page
E. Fosslien
Cancer Morphogenesis: Role of Mitochondrial Failure
Ann. Clin. Lab. Sci., January 1, 2008; 38(4): 307 - 330.
[Abstract] [Full Text] [PDF]

Home page
 Poult. Sci.Home page
H. G. Bao, C. J. Zhao, J. Y. Li, H. Zhang, and Ch. Wu
A Comparison of Mitochondrial Respiratory Function of Tibet Chicken and Silky Chicken Embryonic Brain
Poult. Sci., October 1, 2007; 86(10): 2210 - 2215.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
P. S. Brookes, K. Morse, D. Ray, A. Tompkins, S. M. Young, S. Hilchey, S. Salim, M. Konopleva, M. Andreeff, R. Phipps, et al.
The Triterpenoid 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic Acid and Its Derivatives Elicit Human Lymphoid Cell Apoptosis through a Novel Pathway Involving the Unregulated Mitochondrial Permeability Transition Pore
Cancer Res., February 15, 2007; 67(4): 1793 - 1802.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
H. Sandig, J. E. Pease, and I. Sabroe
Contrary prostaglandins: the opposing roles of PGD2 and its metabolites in leukocyte function
J. Leukoc. Biol., February 1, 2007; 81(2): 372 - 382.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Z. Wang, V. M. Aris, K. D. Ogburn, P. Soteropoulos, and M. E. Figueiredo-Pereira
Prostaglandin J2 Alters Pro-survival and Pro-death Gene Expression Patterns and 26 S Proteasome Assembly in Human Neuroblastoma Cells
J. Biol. Chem., July 28, 2006; 281(30): 21377 - 21386.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. Landar, J. W. Zmijewski, D. A. Dickinson, C. Le Goffe, M. S. Johnson, G. L. Milne, G. Zanoni, G. Vidari, J. D. Morrow, and V. M. Darley-Usmar
Interaction of electrophilic lipid oxidation products with mitochondria in endothelial cells and formation of reactive oxygen species
Am J Physiol Heart Circ Physiol, May 1, 2006; 290(5): H1777 - H1787.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
M. A. Peraza, A. D. Burdick, H. E. Marin, F. J. Gonzalez, and J. M. Peters
The Toxicology of Ligands for Peroxisome Proliferator-Activated Receptors (PPAR)
Toxicol. Sci., April 1, 2006; 90(2): 269 - 295.
[Abstract] [Full Text] [PDF]

Home page
 Annals of Clinical & Laboratory ScienceHome page
E. Fosslien
Cardiovascular Complications of Non-Steroidal Anti-Inflammatory Drugs
Ann. Clin. Lab. Sci., October 1, 2005; 35(4): 347 - 385.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
 All ASBMB Journals   Journal of Biological Chemistry 
 Molecular and Cellular Proteomics   ASBMB Today 
Copyright © 2005 by the American Society for Biochemistry and Molecular Biology.