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A more recent version of this article appeared on March 1, 2005

Papers In Press, published online ahead of print December 16, 2004
J. Lipid Res., doi:10.1194/jlr.M400437-JLR200
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Submitted on November 3, 2004
Revised on December 7, 2004
Accepted on December 7, 2004

The influence of APOA5 polymorphisms on variation in plasma triglycerides in young, healthy African-Americans and Whites of the CARDIA study

Kathy L. E. Klos, Sara Hamon, Andrew G. Clark, Eric Boerwinkle, Kiang Liu, and Charles F. Sing

University of Texas, Houston, TX 77225

Corresponding Author: kklos{at}sph.uth.tmc.edu

Genetic variation in APOA5 has been associated with variation in plasma triglyceride (TG) levels in African-American and White females and males over age 40 years and/or at increased risk of Coronary Artery Disease. We have examined whether plasma TG levels are associated with sixteen APOA5 polymorphisms in young (18-30 years) African-American (1075 females and 783 males) and White individuals (1041females and 932 males) of the CARDIA study selected without regard to health. Plasma TG was significantly (p<0.01) associated with markers 27376 and 28837 (-3A/G) in both White females and males, with 27709 (-1131T/C) and 29085 in White males, 29009 (S19W) in African-American females and White males and with 30966 in African-American females. No statistically significant associations were observed in African-American males. The above six SNPs individually accounted for 0 to 0.78% of lnTG variation among White females, 0 to 2.46% among White males and 0 to 0.69% of variation in African-American females. The results of our study suggest a small, but replicable context-dependent influence of the APOA5 gene region on plasma TG levels in young, healthy individuals.


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