J. Lipid Res.
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A more recent version of this article appeared on February 1, 2005

Papers In Press, published online ahead of print December 1, 2004
J. Lipid Res., doi:10.1194/jlr.M400438-JLR200
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Submitted on November 3, 2004
Revised on December 1, 2004
Accepted on November 22, 2004

Phosphatidylinositol raises HDL cholesterol levels in humans

Jim W. Burgess, Tracey A. M. Neville, Patricia Rouillard, Zdena Harder, Donald S. Beanlands, and Daniel L. Sparks

Lipoprotein and Atherosclerosis Research Group, University of Ottawa Heart Institute, Ottawa, Ontario K1Y4W7

Corresponding Author: dsparks{at}ottawaheart.ca

Studies have shown that phosphatidylinositol (PI) can stimulate reverse cholesterol transport by enhancing the flux of cholesterol into HDL and by promoting the transport of HDL-cholesterol to the liver and bile. The goal of this study was to determine the safety and therapeutic value of PI following oral administration to normolipidemic human subjects. We performed a randomized 2 week study in 16 normolipidemic subjects. Subjects received either 2.8 g or 5.6 g of PI, with or without food. PI was well tolerated by all subjects. PI significantly affected the levels of HDL-C and triglyceride in the plasma of subjects receiving PI with food. The lower dose showed a 13% increase in HDL-C, while those on the high dose showed an increase of 18% over the 2 week period. Both low and high dose groups showed significant elevations in plasma apoA-I. The high dose of PI also decreased plasma triglycerides by 36% in the fed subjects. The data suggest that after only 2 weeks, PI may have a comparable therapeutic value to niacin, with negligible side effects.


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