J. Lipid Res. Neurobiology of Lipids (ISSN1683-5506)
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

A more recent version of this article appeared on October 1, 2005

Papers In Press, published online ahead of print August 1, 2005
J. Lipid Res., doi:10.1194/jlr.M500096-JLR200
This Article
Right arrow Full Text (Accepted Manuscript)
Right arrow All Versions of this Article:
M500096-JLR200v1
46/10/2168    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yoshida, S.
Right arrow Articles by Wada, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yoshida, S.
Right arrow Articles by Wada, Y.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Submitted on March 15, 2005
Revised on July 25, 2005
Accepted on July 27, 2005

Transfer of maternal cholesterol to embryo and fetus in pregnant mice

Shumi Yoshida and Yoshinao Wada

Osaka Medical Center and Research, Osaka University, Institute for Maternal and Child Health, Izumi, Osaka 594-1101

Corresponding Author: s-yoshida{at}mch.pref.osaka.jp

Cholesterol is essential for antenatal development. However, the transport of maternal cholesterol to the embryo has not been sufficiently studied, and that to the fetus is still controversial. To this end, a one mg dose of [3,4-13C2]-cholesterol was injected daily into pregnant mice and the labeled cholesterol was measured by gas chromatography-mass spectrometry. After venous injections from days 10 to 17 of gestation, 13C-cholestrol levels in total (12C- and 13C-) cholesterol were elevated to 5.1% and 2.8% in maternal and fetal plasma, respectively. Labeled cholesterol was identified in the liver, kidneys and intestines, but not in the brain, of the fetus. After injections from days 1 to 8, 13C-cholestrol levels were elevated to 12.4% and 8.0% of total cholesterol in maternal plasma and the embryo, respectively. The level of 11.5% in the yolk sac was higher than that in the embryo. (CONCLUSION) Intrauterine transfer of maternal cholesterol to the embryo as well as the fetus was evident in mice, and both the placenta and yolk sac appear to be the site of intermediate passage in murine pregnancy.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 HypertensionHome page
M. M. Elahi, F. R. Cagampang, F. W. Anthony, N. Curzen, S. K. Ohri, and M. A. Hanson
Statin Treatment in Hypercholesterolemic Pregnant Mice Reduces Cardiovascular Risk Factors in Their Offspring
Hypertension, April 1, 2008; 51(4): 939 - 944.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
F. Jiang and G. E. Herman
Analysis of Nsdhl-deficient embryos reveals a role for Hedgehog signaling in early placental development
Hum. Mol. Genet., November 15, 2006; 15(22): 3293 - 3305.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
G. S. Tint, H. Yu, Q. Shang, G. Xu, and S. B. Patel
The use of the Dhcr7 knockout mouse to accurately determine the origin of fetal sterols
J. Lipid Res., July 1, 2006; 47(7): 1535 - 1541.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
 All ASBMB Journals   Journal of Biological Chemistry 
 Molecular and Cellular Proteomics   ASBMB Today 
Copyright © 2005 by the American Society for Biochemistry and Molecular Biology.