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Papers In Press, published online ahead of print October 12, 2005
J. Lipid Res., doi:10.1194/jlr.M500284-JLR200
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Lipid Research Group, The Heart Research Institute, Camperdown, New South Wales 2050
Corresponding Author: karye{at}ozemail.com.au
The HDL in human plasma are classified on the basis of apolipoprotein composition into those that contain apolipoprotein A-I (apoA-I) without apoA-II, (A-I)HDL, and those containing apoA-I and apoA-II, (A-I/A-II)HDL. ApoA-I is synthesized in the liver and intestine, and secreted into the plasma as discoidal particles complexed with phospholipids. Discoidal (A-I)HDL are remodelled into spherical (A-I)HDL by LCAT. ApoA-II is synthesized in the liver, and is probably also secreted into the plasma as a component of discoidal HDL. As discoidal HDL that contain apoA-II, (A-II)HDL, are poor substrates for LCAT, they are not converted into spherical (A-II)HDL. This study investigates the fate of apoA-II that enters the plasma in either the lipid-free form or as a component of discoidal (A-II)HDL. Lipid-free apoA-II, and apoA-II-containing discoidal reconstituted HDL, (A-II)rHDL, were injected intravenously into New Zealand White rabbits, a species that is naturally deficient in apoA-II, and does not have endogenous (A-I/A-II)HDL. In both cases the apoA-II was rapidly and quantitatively incorporated into spherical HDL that also contained apoA-I to form spherical (A-I/A-II)HDL. These particles were comparable in size and composition to the spherical (A-I/A-II)HDL in human plasma. Injection of lipid-free apoA-II and discoidal (A-II)rHDL into rabbits also resulted in triglyceride-enrichment of the endogenous (A-I)HDL and VLDL, as well as the newly formed (A-I/A-II)HDL. It is concluded that, irrespective of whether apoA-II enters the plasma in the lipid-free form or as a component of discoidal (A-II)rHDL, it is rapidly incorporated into spherical HDL that also contain apoA-I to form (A-I/A-II)HDL.
Revised on September 29, 2005
Accepted on October 11, 2005
Formation of high density lipoproteins containing both apolipoprotein A-I and A-II in the rabbit
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