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Papers In Press, published online ahead of print October 6, 2005
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Brain Physiology and Metabolism Section, National Institute on Aging, NIH, Bethesda, MD 20892
Corresponding Author: sir{at}helix.nih.gov
Male rat pups at weaning (21 days of age) were subjected to a diet deficient or adequate in n-3 polyunsaturated fatty acids (PUFAs) for 15 weeks. Performance on tests of locomotor activity, depression and aggression were measured in that order during the following 3 weeks, after which brain lipid composition was determined. In the n-3 PUFA deprived compared with adequate rats, docosahexaenoic acid (22:6n-3) in brain phospholipid was reduced by 36% and docosapentaenoic acid (22:5n-6) was elevated by 90%, whereas brain phospholipid concentrations were unchanged. N-3 PUFA-deprived rats had a significantly increased (p = 0.03) score on the Porsolt Forced Swim test for depression, and increased blocking time (p = 0.03) and blocking number (p = 0.04) scores (uncorrected for multiple comparisons) on the Isolation Induced Resident Intruder test for aggression. Large “effect sizes” (d > 0.8) were found on the depression score and blocking time score of the aggression test. Scores on the Open Field Test for locomotor activity did not differ significantly between groups, and had only small-to-medium effect sizes. Thus, a single-generational n-3 PUFA deprived rat demonstrated significant changes in brain lipid composition and in test scores of depression and aggression, and may be useful for elucidating the contribution of disturbed brain PUFA metabolism to human depression, aggression and bipolar disorder.
Revised on October 3, 2005
Accepted on October 6, 2005
Dietary N-3 polyunsaturated fatty acid deprivation in rats following weaning increases their behavioral depression and aggression test scores
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