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J. Lipid Res.
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A more recent version of this article appeared on June 1, 2006

Papers In Press, published online ahead of print March 8, 2006
J. Lipid Res., doi:10.1194/jlr.M600029-JLR200
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Submitted on January 18, 2006
Revised on March 7, 2006
Accepted on March 8, 2006

Uptake and metabolism of plasma derived erucic acid by rat brain

Mikhail Y. Golovko and Eric J. Murphy

Pharmacology, Physiology, and Therapeutics, University of North Dakota, Grand Forks, ND 58202-9037

Corresponding Author: emurphy{at}medicine.nodak.edu

We examined the ability of erucic acid (22:1n-9) to cross the blood brain barrier (BBB) by infusing [14-14C]22:1n-9 (170 µCi/kg, i.v. and i.c.v.) into awake, male rats. [1-14C]Arachidonic acid (i.v., 20:4n-6) was the positive control. Following i.v. infusion, 0.011% of the plasma [14-14C]22:1n-9 was extracted by the brain, compared to 0.055% of the plasma [1-14C]20:4n-6. The [14-14C]22:1n-9 was extensively ß-oxidized (60%) as compared to 30% for [1-14C]20:4n-6. While 20:4n-6 was targeted primarily to phospholipid pools, 22:1n-9 was targeted to cholesteryl esters, triglycerides, and phospholipids. When [14-14C]22:1n-9 was infused directly into the fourth ventricle of the brain (i.c.v.) for seven days, 60% of the tracer entered the phospholipid pools, similar to the distribution observed for [1-14C]20:4n-6. This demonstrates plasticity in the ability of the brain to esterify 22:1n-9 in an exposure dependent manner. In i.v. and i.c.v. infused rats, a significant amount of tracer found in the phospholipid pools underwent sequential rounds of chain shortening and was found as [12-14C]20:1n-9 and [10-14C]18:1n-9 fatty acids. These results demonstrate for the first time that intact 22:1n-9 crosses the BBB, is incorporated into specific lipid pools, and is chain shortened.


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