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A more recent version of this article appeared on August 1, 2006

Papers In Press, published online ahead of print May 18, 2006
J. Lipid Res., doi:10.1194/jlr.M600125-JLR200
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Submitted on March 15, 2006
Revised on May 18, 2006
Accepted on May 18, 2006

Absence of VLDL secretion does not affect alpha -tocopherol content in peripheral tissues

Kaori Minehira-Castelli, Scott W. Leonard, Quinn M. Walker, Maret G. Traber, and Stephen G. Young

Medicine, UCLA, Los Angeles, CA 90024

Corresponding Author: sgyoung{at}mednet.ucla.edu

_-Tocopherol is a lipid-soluble antioxidant that helps to prevent oxidative damage to cellular lipids. _-Tocopherol is absorbed by the intestine and is taken up and retained by the liver; it is widely presumed that _-tocopherol is then delivered to peripheral tissues by the secretion of very low density lipoproteins (VLDL). To determine if VLDL secretion is truly important for the delivery of _-tocopherol to peripheral tissues, we examined _-tocopherol metabolism in mice that lack microsomal triglyceride transfer protein (Mttp) expression in the liver and therefore cannot secrete VLDL (Mttpî/î mice). Mttpî/î mice have low plasma lipid levels and elevated stores of lipids in the liver. Similarly, ±-tocopherol levels in the plasma were lower in Mttpî/î mice than in controls, while hepatic ±-tocopherol stores were higher. However, the ±-tocopherol levels in the peripheral tissues of Mttpî/î mice were nearly identical to those of control mice, suggesting that VLDL secretion is not critical for the delivery of ±-tocopherol to peripheral tissues. When fed a diet containing deuterated ±-tocopherol, Mttpî/î and control mice had similar incorporation of deuterated ±-tocopherol into plasma and various peripheral tissues. We conclude that the absence of VLDL secretion has little effect on the stores of ±-tocopherol in peripheral tissues, at least in the mouse.


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