Advertisement
J. Lipid Res.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

A more recent version of this article appeared on February 1, 2007

Papers In Press, published online ahead of print November 18, 2006
J. Lipid Res., doi:10.1194/jlr.M600283-JLR200
This Article
Right arrow Full Text (Accepted Manuscript)
Right arrow All Versions of this Article:
M600283-JLR200v1
48/2/278    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Petit, V.
Right arrow Articles by Niot, I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Petit, V.
Right arrow Articles by Niot, I.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Submitted on June 30, 2006
Revised on November 10, 2006
Accepted on November 18, 2006

Chronic high-fat diet affects the intestinal fat absorption and postprandial triglycerides levels in the mouse

Valerie Petit, Laurent Arnould, Pascal Martin, Marie-Claude Monnot, Thierry Pineau, Philippe Besnard, and Isabelle Niot

Physiology of Nutrition, ENSBANA, Dijon 21000

Corresponding Author: niot{at}u-bourgogne.fr

Impacts of a chronic fat over-consumption on the intestinal physiology and lipid metabolism remains elusive. It is unknown whether a fat-mediated adaptation of lipid absorption takes place. To address this issue, mice fed a high-fat diet (40%, m/m) were re-fed or not a control diet (3%, m/m) for 3 additive weeks. Despite daily lipid intake 7.7 fold higher than in controls, the faecal lipid output remained unchanged in mice fed the triglyceride-rich diet. In situ isolated jejunal loops revealed a greater [1-14C] linoleic acid uptake without triglyceride accumulation in mucosa, suggesting an increase in the lipid absorption capacity. An induction both in intestinal mitotic index and in the expression of genes involved in fatty acid uptake, trafficking and lipoprotein synthesis were found in high-fat diet mice. These changes was lipid-mediated since they were fully abolished in mice refed the control diet. Lipid load test performed in presence or absence of the lipoprotein lipase (LPL) inhibitor Tyloxapol showed a sustained blood triglycerides clearance in fat-fed mice likely due to intestinal modulation of LPL regulators (apolipoprotein C-II and C-III). These data demonstrate that a chronic high-fat diet greatly affect the intestinal physiology and body lipid use in the mouse.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
K. A. Longo, S. Charoenthongtrakul, D. J. Giuliana, E. K. Govek, T. McDonagh, P. S. DiStefano, and B. J. Geddes
The 24-hour respiratory quotient predicts energy intake and changes in body mass
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2010; 298(3): R747 - R754.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
Z. Chen, E. P. Newberry, J. Y. Norris, Y. Xie, J. Luo, S. M. Kennedy, and N. O. Davidson
ApoB100 is required for increased VLDL-triglyceride secretion by microsomal triglyceride transfer protein in ob/ob mice
J. Lipid Res., September 1, 2008; 49(9): 2013 - 2022.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
 All ASBMB Journals   Journal of Biological Chemistry 
 Molecular and Cellular Proteomics   ASBMB Today 
Copyright © 2006 by the American Society for Biochemistry and Molecular Biology.
Advertisement
spacer
Advertisement
Advertisement