J. Lipid Res. Neurobiology of Lipids (ISSN1683-5506)
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A more recent version of this article appeared on November 1, 2006

Papers In Press, published online ahead of print August 3, 2006
J. Lipid Res., doi:10.1194/jlr.M600288-JLR200
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Submitted on July 5, 2006
Accepted on August 3, 2006

Protective effect of apolipoprotein E2 on coronary artery disease in African Americans is mediated through lipoprotein cholesterol

Erdembileg Anuurad, Jill Rubin, Guijing Lu, Thomas A. Pearson, Steve Holleran, Rajasekhar Ramakrishnan, and Lars Berglund

Medicine, University of California Davis, Sacramento, CA 95817

Corresponding Author: lars.berglund{at}ucdmc.ucdavis.edu

We studied the relationship of apolipoprotein E (apo E) to coronary artery disease (CAD) in 224 African Americans and 326 Caucasians undergoing coronary angiography. Presence of CAD was defined as >50% stenosis in at least one artery. Apo E allele frequencies were 0.12, 0.62 and 0.26 for e2, e3 and e4, respectively, in African Americans, and 0.08, 0.78 and 0.14 for e2, e3, and e4, respectively, in Caucasians. Among African Americans, CAD was present in 9 of 34 e2-carriers (26%), significantly smaller (P<0.05) in proportion compared to 39 of 82 e3- and 43 of 92 e4-carriers (48% and 47%, respectively), suggesting a protective effect of e2. No such difference was seen in Caucasians. In African Americans, but not Caucasians, LDL cholesterol was lower in e2-carriers than in e3- and e4-carriers (106 vs. 127 and 134 mg/dl, P<0.005, respectively). After adjusting for lipid levels, the association between apo e2 and CAD was no longer significant. Thus, the protective effect of apo e2 seen in African Americans could be explained by a favorable lipid profile in e2-carriers, while in Caucasians, the absence of such a protective effect could be due to the lack of effect of apo e2 on the lipid profile.


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