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A more recent version of this article appeared on March 1, 2007

Papers In Press, published online ahead of print December 15, 2006
J. Lipid Res., doi:10.1194/jlr.M600431-JLR200
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Submitted on September 29, 2006
Revised on December 13, 2006
Accepted on December 15, 2006

APO E genotype affect allele-specific APO(a) levels for large APO(a) sizes in African Americans: The harlem-basset study

Erdembileg Anuurad, Guijing Lu, Jill Rubin, Thomas A. Pearson, and Lars Berglund

Medicine, University of California Davis, Sacramento, CA 95817

Corresponding Author: lars.berglund{at}ucdmc.ucdavis.edu

Genetic variability of apolipoprotein E (apoE) influences plasma lipoprotein levels, and allele frequencies differ between African Americans and Caucasians. As African Americans have higher Lp(a) levels than Caucasians, we investigated the effects of the apoE gene on allele-specific apo(a) levels across ethnicity. We determined apo(a) sizes, allele-specific apo(a) levels (i.e. levels associated with alleles defined by size) and the apoE gene polymorphism in 231 African Americans and 336 Caucasians. African Americans, but not Caucasians, with apo e2 genotype had lower levels of Lp(a) compared to those with apo e4 (9.6 vs. 11.2 nmol/L, P=0.034, expressed as square root levels). Distribution of apo(a) alleles across apoE genotypes were similar between African Americans and Caucasians. Among African Americans with large size apo(a), the allele-specific apo(a) level was significantly lower among e2-carriers compared to e3- or e4-carriers (5.4 vs. 6.6 and 7.4 nmol/L; P<0.005, expressed as square root levels), respectively. In contrast, there was no significant difference in allele-specific apo(a) levels across apoE genotype among Caucasians. For large apo(a) sizes, apoE genotype contributed to observed African American-Caucasian differences in allele-specific apo(a) levels.


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This article has been cited by other articles:


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E. Anuurad, J. Rubin, A. Chiem, R. P. Tracy, T. A. Pearson, and L. Berglund
High Levels of Inflammatory Biomarkers Are Associated with Increased Allele-Specific Apolipoprotein(a) Levels in African-Americans
J. Clin. Endocrinol. Metab., April 1, 2008; 93(4): 1482 - 1488.
[Abstract] [Full Text] [PDF]


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