Advertisement
J. Lipid Res.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

A more recent version of this article appeared on October 1, 2007

Papers In Press, published online ahead of print July 3, 2007
J. Lipid Res., doi:10.1194/jlr.M700009-JLR200
This Article
Right arrow Full Text (Accepted Manuscript)
Right arrow Supplemental Data
Right arrow All Versions of this Article:
M700009-JLR200v1
48/10/2182    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Moen, C. J. A.
Right arrow Articles by Rensen, P. C. N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Moen, C. J. A.
Right arrow Articles by Rensen, P. C. N.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Submitted on January 8, 2007
Revised on June 28, 2007
Accepted on June 30, 2007

The Hyplip2 locus causes hypertriglyceridemia by decreased clearance of triglycerides

Corina J. A. Moen, Aart P. Tholens, Peter J. Voshol, Willeke de Haan, Louis M. Havekes, Peter Gargalovic, Aldons J. Lusis, Ko Willems van Dijk, Rune R. Frants, Marten H. Hofker, and Patrick C. N. Rensen

Dept. of Human Genetics, Leiden University Medical Center, Leiden 2300 RC

Corresponding Author: cmoen{at}lumc.nl

Objective - The Hyplip2 congenic mouse strain contains part of chromosome 15 from MRL/MpJ on BALB/cJ (B/c) background. Hyplip2 mice show elevated plasma levels of cholesterol and predominantly triglycerides (TG), and are susceptible to diet-induced atherosclerosis. This study aimed at elucidation of the mechanism(s) explaining the hypertriglyceridemia. Methods and Results - Hypertriglyceridemia can result from an increased intestinal or hepatic TG production and/or by a decreased LPL-mediated TG clearance. The intestinal TG absorption and chylomicron formation was studied after i.v. injection of Triton WR1339 and intragastric load of olive oil containing glycerol tri[3H]oleate. No difference was found in intestinal TG absorption. Moreover, the hepatic VLDL-TG production rate and VLDL particle production, after injection of Triton WR1339, were also not affected. To investigate the LPL-mediated TG clearance, mice were injected i.v. with glycerol tri[3H]oleate-labeled VLDL-like emulsion particles. In Hyplip2 mice, the particles were cleared at a decreased rate (t½ 25±6 vs 11±2 min, p<0.05) concomitant with decreased uptake of emulsion-TG derived 3H-labeled fatty acids by the liver and white adipose tissue. Conclusion - The increased plasma TG levels in Hyplip2 mice do not result from an enhanced intestinal absorption or increased hepatic VLDL-production, but are caused by decreased LPL-mediated TG clearance.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Circ Cardiovasc GenetHome page
P. S. Gargalovic, A. Erbilgin, O. Kohannim, J. Pagnon, X. Wang, L. Castellani, R. LeBoeuf, M. L. Peterson, B. T. Spear, and A. J. Lusis
Quantitative Trait Locus Mapping and Identification of Zhx2 as a Novel Regulator of Plasma Lipid Metabolism
Circ Cardiovasc Genet, February 1, 2010; 3(1): 60 - 67.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
C. Zhou, N. King, K. Y. Chen, and J. L. Breslow
Activation of PXR induces hypercholesterolemia in wild-type and accelerates atherosclerosis in apoE deficient mice
J. Lipid Res., October 1, 2009; 50(10): 2004 - 2013.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
R. L.M. van der Ham, R. A. Dehnavi, J. F.P. Berbee, H. Putter, A. de Roos, J. A. Romijn, P. C.N. Rensen, and J. T. Tamsma
Plasma Apolipoprotein CI and CIII Levels Are Associated With Increased Plasma Triglyceride Levels and Decreased Fat Mass in Men With the Metabolic Syndrome
Diabetes Care, January 1, 2009; 32(1): 184 - 186.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
 All ASBMB Journals   Journal of Biological Chemistry 
 Molecular and Cellular Proteomics   ASBMB Today 
Copyright © 2007 by the American Society for Biochemistry and Molecular Biology.
Advertisement
spacer
Advertisement
Advertisement