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Papers In Press, published online ahead of print August 10, 2007
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Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1679
Corresponding Author: bvanlent{at}mednet.ucla.edu
Rabbits on a 1% cholesterol diet received injections of vehicle with or without D-4F or L-4F. After 1 month the percent of aorta with atherosclerotic lesions was 24 ± 15% (vehicle), 10 ± 6% (D-4F) (p<0.01 versus vehicle), and 13 ± 9% (L-4F) (p<0.05 versus vehicle). Inflammatory indexes for HDL and LDL were determined by measuring monocyte chemotactic activity after adding rabbit lipoproteins to human endothelial cells. HDL-inflammatory index (HII) and LDL-inflammatory index (LII), respectively, were 1.39 ± 0.24; 1.35 ± 0.29 (vehicle), 0.67 ± 0.26; 0.63 ± 0.38 (D-4F) (p<0.001 versus vehicle), and 0.67 ± 0.2; 0.68 ± 0.32 (L-4F) (p<0.01 versus vehicle). Serum amyloid A (SAA) levels were 95 ± 39, 8 ± 22, and 7 ± 19 µg/mL, respectively, for vehicle, D-4F, and L-4F (p <0.001 versus vehicle). There was no correlation between lesion area and total plasma or HDL-cholesterol levels. In contrast, there was a positive correlation with HII, LII, and SAA (p = 0.002, p = 0.0026, p = 0.0079, respectively). HII correlated closely with SAA levels (r =0.6616; r2 =0.4377, p<0.0001). Thus, HII, LII and SAA are better predictors of lesion area than total plasma or HDL-cholesterol levels in cholesterol-fed rabbits.
Revised on August 7, 2007
Accepted on August 9, 2007
Lipoprotein inflammatory properties and serum amyloid a levels but not cholesterol levels predict lesion area in cholesterol-fed rabbits
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