Advertisement
J. Lipid Res.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

A more recent version of this article appeared on March 1, 2008

Papers In Press, published online ahead of print December 5, 2007
J. Lipid Res., doi:10.1194/jlr.M700510-JLR200
This Article
Right arrow Full Text (Accepted Manuscript)
Right arrow Supplemental Data
Right arrow All Versions of this Article:
M700510-JLR200v1
49/3/635    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Catalano, G.
Right arrow Articles by Guerin, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Catalano, G.
Right arrow Articles by Guerin, M.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Submitted on November 7, 2007
Revised on December 5, 2007
Accepted on December 5, 2007

Cellular SR-BI and ABCA1-mediated cholesterol efflux are gender specific in healthy subjects

Giovanna Catalano, Emilie Duchene, Zélie Julia, Wilfried Le Goff, Eric Bruckert, M. John Chapman, and Maryse Guerin

INSERM Unit 551, INSERM, Paris 75651

Corresponding Author: mguerin{at}chups.jussieu.fr

We evaluated the impact of gender differences in both the quantitative and qualitative features of HDL subspecies on cellular free cholesterol (FC) efflux through the SR-BI, ABCA1 or ABCG1 pathways. For that purpose, healthy subjects (30 men and 26 women) matched for age, BMI, triglyceride, apoAI and HDL-cholesterol levels were recruited. We observed a significant elevation (+14%; p<0.03) in the capacity of whole sera from women to mediate cellular FC efflux via the SR-BI-dependent pathway as compared to sera from men. Such enhanced efflux capacity resulted from significant elevation in plasma levels of large CE-rich HDL2 particles (+20%; p<0.04), as well as from an enhanced capacity (+14%; p<0.03) of these particles to mediate cellular FC efflux via SR-BI. By contrast, plasma from men displayed an enhanced FC efflux capacity (+31%; p<0.001) via the ABCA1 transporter pathway as compared to that from women which result from a 2.4-fold increase in plasma level of pre- particles (p<0.008). Moreover in women, SR-BI-mediated cellular FC efflux was significantly correlated with plasma HDL-C (r=0.72; p<0.0001), whereas this relationship was not observed in men. In conclusion, HDL-C level may not represent the absolute indicator of the efficiency of the initial step of the reverse cholesterol transport.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Lipid Res.Home page
N. Mukhamedova, G. Escher, W. D'Souza, U. Tchoua, A. Grant, Z. Krozowski, M. Bukrinsky, and D. Sviridov
Enhancing apolipoprotein A-I-dependent cholesterol efflux elevates cholesterol export from macrophages in vivo
J. Lipid Res., November 1, 2008; 49(11): 2312 - 2322.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
 All ASBMB Journals   Journal of Biological Chemistry 
 Molecular and Cellular Proteomics   ASBMB Today 
Copyright © 2007 by the American Society for Biochemistry and Molecular Biology.
Advertisement
spacer
Advertisement
Advertisement