Submitted on May 9, 2008
Accepted on May 23, 2008
Differences in DBA/1J and DBA/2J reveal lipid QTL genes
Ioannis M. Stylianou, Sarah R. Langley, Kenneth Walsh, Yuan Chen, Céline Revenu, and Beverly Paigen
The Jackson Laboratory, The Jackson Laboratory, Bar Harbor, ME 04609
Corresponding Author: bev.paigen{at}jax.org
Recent advances in mouse genomics have revealed considerable variation in the form of single nucleotide polymorphisms (SNPs) among common inbred strains. This has made it possible to characterize closely related strains and to identify genes that differ; such a gene may be causal for quantitative phenotypes. The mouse strains DBA/1J and DBA/2J differ by just 5.6% at the SNP level. These strains exhibit differences in a number of metabolic and lipid phenotypes such as plasma levels of triglycerides and high density lipoproteins. A cross between these strains revealed multiple QTL in 294 progeny. We identified significant triglyceride QTL on Chr 1, 2, 3, 4, 8, 9, 10, 11, 12, 13, 14, 16 and 19, and significant HDL QTL on chromosomes 3, 9 and 16. Some QTL mapped to chromosomes with limited variability between the two strains, thus facilitating the identification of candidate genes. We suggest that Tshr is the QTL gene for Chr 12 triglyceride and HDL levels and that Ihh may account for the triglyceride QTL on Chr 1. This cross highlights the advantage of crossing closely related strains for subsequent identification of QTL genes.
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