Submitted on May 22, 2008
Revised on July 7, 2008
Accepted on July 8, 2008
Replacement of dietary saturated fatty acids by polyunsaturated fatty acids in diet and reverse cholesterol transport
Ivana Kralova Lesna, Pavel Suchanek, Jan Kovar, Petr Stavek, and Rudolf Poledne
Center for Cardiovascular Research, Institute of clinical and experimental medicine, Prague, Czech republic 140 21
Corresponding Author: ivka{at}ikem.cz
Dietary intervention is the first and usually successful approach in treatment of high LDL cholesterol concentration, but it is frequently accompanied by a decrease in HDL concentration. We studied 14 male volunteers on two different diets, high saturated (SFA) and high polyunsaturated fatty acids (PUFA) in a cross-over design to test if HDL decrease can effect also reverse cholesterol transport from relabeled macrophages. A significant decrease of LDL cholesterol (in mmol/l) after PUFA diet compared to SFA diet from 3.15 ± 0.65 to 2.80 ± 0.56 (p<0.01) was accompanied by significant decrease of HDL cholesterol (in mmol/l) from 1.21 ± 0.30 to 1.10 ± 0.32 (p<0.05). These changes did not affect cholesterol efflux from macrophages (9.74 ± 1.46 % vs. 9.53 ± 1.41 %). There was no correlation between individual changes of HDL cholesterol and changes of cholesterol efflux. It is concluded that the decrease of HDL cholesterol after successful dietary intervention of LDL cholesterol is not accompanied by a decrease of cholesterol efflux.
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