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J. Lipid Res.
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A more recent version of this article appeared on March 1, 2009

Papers In Press, published online ahead of print November 5, 2008
J. Lipid Res., doi:10.1194/jlr.M800456-JLR200
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Submitted on August 25, 2008
Revised on October 20, 2008
Accepted on November 4, 2008

Polymorphisms at newly identified lipid associated loci are associated with blood lipids and cardiovascular disease an Asian Malay population

E. Shyong Tai, Xue Ling Sim, Twee Hee Ong, Tien Ying Wong, Seang Mei Saw, Tin Aung, Sekar Kathiresan, Marju Orho-Melander, Jose M. Ordovas, Jonathan T. Tan, and Mark Seielstad

Department of Endocrinology, Singapore General Hospital, Singapore 169608

Corresponding Author: eshyong{at}pacific.net.sg

We conducted a cross-sectional study of Malay participants aged 40-80 (n=2932) to examine the associations between polymorphisms at newly identified, lipid associated, loci with blood lipid levels and prevalent cardiovascular disease (CVD) in a Malay population in Asia. A polymorphism adjacent to the TRIB1 locus (rs17321515) was associated with elevated total cholesterol and LDL-C after adjustment for age and sex (both p-values < 0.007) and with increased risk of CHD and CVD (OR 1.23; 95% CI 1.03-1.46 and OR 1.2; 95% CI 1.02-1.42 respectively) under an additive model of inheritance. In addition, using recessive models of inheritance, polymorphisms on chromosome 19 adjacent to the CILP2 and PBX4 loci (rs16996148) and on chromosome 1 at the GALNT2 locus (rs4846914) were associated with elevated HDL-C (p=0.005) and lower LDL-C (p=0.048) respectively. Although novel, the former is consistent with the association between this polymorphism and lower blood triglycerides observed in the initial studies conducted in populations of European ancestry. Neither showed statistically significant association with CVD. These observations should form the basis of further investigation to identify the causative polymorphisms at this locus, and also understand the mechanistic roles that this protein may play in lipoprotein metabolism in Asians and other populations.


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[Abstract] [Full Text] [PDF]


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