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J. Lipid Res.
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A more recent version of this article appeared on December 1, 2006

Papers In Press, published online ahead of print September 15, 2006
J. Lipid Res., doi:10.1194/jlr.P600002-JLR200
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Submitted on May 30, 2006
Revised on August 30, 2006
Accepted on September 14, 2006

Endothelial lipase is associated with inflammation in humans

Marie-Eve Paradis, Karen O. Badellino, Daniel J. Rader, Yves Deshaies, Patrick Couture, Wiedad R. Archer, Nathalie Bergeron, and Benoît Lamarche

INAF, Nutraceuticals and Functional Foods Institute, Québec, Québec G1K 7P4

Corresponding Author: marie-eve.paradis{at}inaf.ulaval.ca

The aim of the present study was to investigate the extent to which inflammation is linked with plasma EL concentrations among healthy sedentary men. Plasma C-reactive protein (CRP) concentrations were measured with a highly sensitive commercial immunoassay, plasma interleukin-6 (IL-6) concentrations were measured using a commercial ELISA and plasma sPLA2-IIA were measured using a commercial assay in a sample of 74 moderately obese men (mean body mass index: 29.8 ± 5.2 kg/m2). Plasma EL concentrations were positively correlated with various indices of obesity, fasting plasma insulin, and plasma CRP, IL-6 and sPLA2-IIA concentrations. Multiple regression analyses revealed that plasma CRP concentrations explained 14.5% (P=0.0008) of the variance in EL concentrations. When entered into the model, LPL activity accounted for 16.1% (P<0.0001) and plasma CRP concentrations for 20.9% (P<0.0001) of the variance in EL concentrations. The combined impact of visceral adipose tissue (VAT) and of an inflammation score on EL concentrations was investigated. Among subjects with high or low VAT, those having a high inflammation score based on plasma CRP, IL-6 and sPLA2-IIA concentrations had elevated plasma EL concentrations (P=0.0005). In conclusion, our data revealed a strong association between pro-inflammatory cytokines and plasma EL concentrations among healthy people with low or high VAT levels.


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