J. Lipid Res. Acyl Labeled PIP's available August 1, 2008
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

A more recent version of this article appeared on December 1, 2006

Papers In Press, published online ahead of print September 18, 2006
J. Lipid Res., doi:10.1194/jlr.P600005-JLR200
This Article
Right arrow Full Text (Accepted Manuscript)
Right arrow All Versions of this Article:
P600005-JLR200v1
47/12/2814    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Erkkilä, A. T.
Right arrow Articles by Lichtenstein, A. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Erkkilä, A. T.
Right arrow Articles by Lichtenstein, A. H.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Submitted on June 9, 2006
Revised on September 18, 2006
Accepted on September 18, 2006

Higher plasma docosahexaenoic acid is associated with reduced progression of coronary-artery atherosclerosis in women with established coronary artery disease

Arja T. Erkkilä, Nirupa R. Matthan, David M. Herrington, and Alice H. Lichtenstein

School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio 70211

Corresponding Author: arja.erkkila{at}uku.fi

Fish, fish oil supplement, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and in some cases alpha-linolenic acid (ALA) intake have been associated with reduced risk of cardiovascular events and death. The association between n-3 fatty acids in plasma lipids and progression of coronary-artery atherosclerosis was assessed among women with established coronary artery disease (CAD). A prospective cohort study involved postmenopausal women (n=228) participating in the Estrogen Replacement and Atherosclerosis trial. Quantitative coronary angiography was performed at baseline and after 3.2±0.6 (mean±SD) years. Women with plasma phospholipid DHA levels above the median, compared to below, exhibited less atherosclerosis progression as expressed by decline in minimum coronary artery diameter (-0.04±0.02 mm and -0.10±0.02 mm, respectively, P=0.007), or increase in percent stenosis (1.34±0.76% and 3.75±0.74%, respectively, P=0.006) and had fewer new lesions [2.0 (0.5-3.5) % of measured segments (95% confidence interval)] and 4.2 (2.8-5.6)%, respectively, P=0.009] after adjustments for cardiovascular risk factors. Similar results were observed for DHA in the triglycerides. EPA and ALA in plasma lipids were not significantly associated with atherosclerosis progression. Consistent with higher reported fish intake, higher levels of plasma triglyceride and phospholipid DHA is associated with less progression of coronary atherosclerosis in postmenopausal women with established CAD.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
W.-L. Song, J. A. Lawson, D. Reilly, J. Rokach, C.-T. Chang, B. Giasson, and G. A. FitzGerald
Neurofurans, Novel Indices of Oxidant Stress Derived from Docosahexaenoic Acid
J. Biol. Chem., January 4, 2008; 283(1): 6 - 16.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
 All ASBMB Journals   Journal of Biological Chemistry 
 Molecular and Cellular Proteomics   ASBMB Today 
Copyright © 2006 by the American Society for Biochemistry and Molecular Biology.