Submitted on May 29, 2007
Revised on December 17, 2007
Accepted on December 18, 2007
Effects of 1,3-diacylglycerol oil-enriched diet on postprandial lipemia in people with insulin resistance
Gissette Reyes, Koichi Yasunaga, Eileen Rothenstein, Wahida Karmally, Rajasekhar Ramakrishnan, Stephen Holleran, and Henry N. Ginsberg
Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032
Corresponding Author: hng1{at}columbia.edu
Postprandial hypertriglyceridemia is common in individuals with insulin resistance (IR), and diets enriched in 1,3-diacylglycerol (DAG) may reduce postprandial plasma triglycerides (PPTG). We enrolled 25 insulin resistant, non-diabetic individuals in a double-blind, randomized crossover trial to test acute and chronic effects of a DAG-enriched diet on PPTG. Participants received either DAG or triacylglycerol (TAG) oil, in food products, for 5 weeks. Fasting lipids, and two separate postprandial tests, one with DAG oil and one with TAG oil, were performed at the end of each 5-week diet period. We found no acute or chronic effects of DAG oil on PPTG. Thus, neither the DAG oil PPTG (h.mg/dl) on a chronic TAG diet (area under the curve, AUC: 503 ±439) nor the TAG oil PPTG on a chronic DAG diet (AUC: 517 ±638) were different from the TAG oil PPTG on a chronic TAG diet (AUC: 565 ± 362). Conclusion: Five weeks of a DAG-enriched diet had no acute or chronic effects on PPTG in insulin resistant individuals. We suggest further studies to evaluate effects of DAG on individuals with low and high TG levels.
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