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A more recent version of this article appeared on March 1, 2004

Papers In Press, published online ahead of print December 1, 2003
J. Lipid Res., doi:10.1194/jlr.R300006-JLR200
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Submitted on June 9, 2003
Revised on November 4, 2003
Accepted on November 18, 2003

Discovery of new G-protein-coupled receptors for lipid mediators

Dong-Soon Im

College of Pharmacy, Pusan National University, Busan, Busan 609-735

Corresponding Author: imds{at}pusan.ac.kr

Successful sequencing of the human genome has opened a new era in the life sciences and has greatly accelerated biomedical research. Among various research endeavors benefiting from established genomic information, one of the most fruitful areas would be the research on orphan G protein-coupled receptors (GPCRs). Many intercellular mediators, including peptides, lipids, and other small molecules, have found their GPCRs in the plasma membrane; for example, relaxin and tyramine. In the past fourteen months, more than one dozen papers have been published reporting the finding of intercellular lipid mediators acting on rhodopsin-family GPCRs. This review focuses primarily on intercellular lipid mediators and their recently discovered GPCRs.


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