Cholesterol: from heart attacks to Alzheimer's disease

Robert L. Raffai and Karl H. Weisgraber

Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94141-9100

Corresponding Author: kweisgraber{at}gladstone.ucsf.edu

Abstract The accumulation and aggregation of the amyloid-ß peptide (Aß) in the brain are important contributing factors to Alzheimer’s disease (AD). Consequently, blocking the generation of Aß is a potentially important treatment strategy. Recent work on the metabolism of Aß has identified several cellular proteins and proteases that collectively promote or prevent the generation of Aß. In addition, accumulating in vitro and in vivo evidence suggests a role for cholesterol in modulating the cellular processing of Aß with the potential to affect AD.

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