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Papers In Press, published online ahead of print September 1, 2003
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R&D, VACHCS-West Side VA Medical Center, Department of Anesthesiology, University of Illinois at Chicago, Chicago, IL 60612
Corresponding Author: nchauhan{at}uic.edu
Alzheimers disease (AD) is characterized by deposition of -amyloid (A) plaques derived from amyloidogenic processing of a transmembrane -amyloid precursor protein (APP). Besides the known genetic/sporadic factors that promote the formation of A, composition and structural dynamics of the membrane also are implicated to play a significant role in the amyloidogenic processing of APP that seeds A. This mini-review reinforces the roles played by membrane dynamics, membrane-microdomains and cholesterol homeostasis in relation to amyloidogenesis, and reviews current strategies of lowering cholesterol in treating Alzheimers disease.
Revised on September 1, 2003
Accepted on August 24, 2003
Membrane dynamics, cholesterol homeostasis and Alzheimer's disease
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