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J. Lipid Res.
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A more recent version of this article appeared on November 1, 2003

Papers In Press, published online ahead of print September 1, 2003
J. Lipid Res., doi:10.1194/jlr.R300010-JLR200
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Submitted on July 3, 2003
Revised on September 1, 2003
Accepted on August 24, 2003

Membrane dynamics, cholesterol homeostasis and Alzheimer's disease

Neelima B. Chauhan

R&D, VACHCS-West Side VA Medical Center, Department of Anesthesiology, University of Illinois at Chicago, Chicago, IL 60612

Corresponding Author: nchauhan{at}uic.edu

Alzheimer’s disease (AD) is characterized by deposition of -amyloid (A) plaques derived from amyloidogenic processing of a transmembrane -amyloid precursor protein (APP). Besides the known genetic/sporadic factors that promote the formation of A, composition and structural dynamics of the membrane also are implicated to play a significant role in the amyloidogenic processing of APP that seeds A. This mini-review reinforces the roles played by membrane dynamics, membrane-microdomains and cholesterol homeostasis in relation to amyloidogenesis, and reviews current strategies of lowering cholesterol in treating Alzheimer’s disease.


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