|
 |
|
|||||||
|
|||||||||
Papers In Press, published online ahead of print September 16, 2003
J. Lipid Res., doi:10.1194/jlr.R300013-JLR200
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Neuroscience Center and Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, LA 70112
Corresponding Author: nbazan{at}lsuhsc.edu
The highly networked organization of the nervous system encompasses a variety of cells that display, as a distinctive feature, one of the largest membrane surface areas of all cells. This would be very clearly illustrated if the plasma membrane from a neuron (e.g., hippocampal CA1 or Purkinje cell of the cerebellum) could be spread out on a flat surface: the branching and complexities of dendrites that form the dendritic spines are very extensive, largely comprising postsynaptic elements. An important additional feature of neuronal dendrites is that they undergo dramatic changes in shape and length during development and learning; they are also affected in aging and in several pathologic conditions. Astrocytes, oligodendrocytes, and microglial cells have very large plasma membrane surface areas as well. To add a further level of complexity, all of these cells extensively interact with neurons. How membranes are organized has conceptually evolved from the lipid bilayer with embedded proteins to a highly dynamic, heterogeneous patchwork of microdomains that contain ion channels, receptors, transporters, and other proteins. Cellular membranes in the nervous system were divided in the past into relatively more fluid membranes (e.g., those of cells of gray matter) and relatively more rigid membranes (e.g., oligodendrocyte plasma membrane that spirals around the axon to form the myelin), according to the higher or lower content of polyunsaturated fatty acids (PUFA) in phospholipids. Currently in neurons, glia, and endothelial cells of the cerebrovasculature, several phospholipid pools are increasingly being recognized as reservoirs of lipid messengers. Specific lipid messengers are cleaved from these reservoir phospholipids by phospholipases upon stimulation by neurotransmitters, neurotrophic factors, cytokines, membrane depolarization, ion channel activation, etc. Lipid messengers regulate and interact with multiple other signaling cascades, contributing to the development, differentiation, function, protection, and repair of the cells of the nervous system.
Revised on September 2, 2003
Accepted on September 5, 2003
Synaptic lipid signaling: significance of polyunsaturated fatty acids and platelet-activating factor
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  W. J. Lukiw and N. G. Bazan Docosahexaenoic Acid and the Aging Brain J. Nutr., December 1, 2008; 138(12): 2510 - 2514. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Lavialle, G. Champeil-Potokar, J. M. Alessandri, L. Balasse, P. Guesnet, C. Papillon, P. Pevet, S. Vancassel, B. Vivien-Roels, and I. Denis An (n-3) Polyunsaturated Fatty Acid-Deficient Diet Disturbs Daily Locomotor Activity, Melatonin Rhythm, and Striatal Dopamine in Syrian Hamsters J. Nutr., September 1, 2008; 138(9): 1719 - 1724. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. G. Bazan Homeostatic Regulation of Photoreceptor Cell Integrity: Significance of the Potent Mediator Neuroprotectin D1 Biosynthesized from Docosahexaenoic Acid The Proctor Lecture Invest. Ophthalmol. Vis. Sci., November 1, 2007; 48(11): 4866 - 4881. [Full Text] [PDF]
|
|
|
|
 |
|
 W. L. Huang, V. R. King, O. E. Curran, S. C. Dyall, R. E. Ward, N. Lal, J. V. Priestley, and A. T. Michael-Titus A combination of intravenous and dietary docosahexaenoic acid significantly improves outcome after spinal cord injury Brain, November 1, 2007; 130(11): 3004 - 3019. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z.-G. Zhao, M. Zhang, X.-M. Zeng, X.-W. Fei, L.-Y. Liu, Z.-H. Zhang, and Y.-A. Mei Flufenamic Acid Bi-Directionally Modulates the Transient Outward K+ Current in Rat Cerebellar Granule Cells J. Pharmacol. Exp. Ther., July 1, 2007; 322(1): 195 - 204. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Shen, K. Kishimoto, D. J. Linden, and A. Sapirstein Cytosolic phospholipase A2 alpha mediates electrophysiologic responses of hippocampal pyramidal neurons to neurotoxic NMDA treatment PNAS, April 3, 2007; 104(14): 6078 - 6083. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Kan, E. Melamed, D. Offen, and P. Green Docosahexaenoic acid and arachidonic acid are fundamental supplements for the induction of neuronal differentiation J. Lipid Res., March 1, 2007; 48(3): 513 - 517. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Chemin, J. Nargeot, and P. Lory Chemical Determinants Involved in Anandamide-induced Inhibition of T-type Calcium Channels J. Biol. Chem., January 26, 2007; 282(4): 2314 - 2323. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Duffield, S. Hong, V. S. Vaidya, Y. Lu, G. Fredman, C. N. Serhan, and J. V. Bonventre Resolvin D Series and Protectin D1 Mitigate Acute Kidney Injury J. Immunol., November 1, 2006; 177(9): 5902 - 5911. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Akaneya and T. Tsumoto Bidirectional Trafficking of Prostaglandin E2 Receptors Involved in Long-Term Potentiation in Visual Cortex J. Neurosci., October 4, 2006; 26(40): 10209 - 10221. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Sang and C. Chen Lipid Signaling and Synaptic Plasticity Neuroscientist, October 1, 2006; 12(5): 425 - 434. [Abstract] [PDF]
|
|
|
|
|
|
Z. Faghiri and N. G. Bazan Selective Relocalization and Proteasomal Downregulation of PKC{alpha} Induced by Platelet-Activating Factor in Retinal Pigment Epithelium Invest. Ophthalmol. Vis. Sci., January 1, 2006; 47(1): 397 - 404. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. He, N. G. Bazan, and H. E. P. Bazan Alkali-Induced Corneal Stromal Melting Prevention by a Novel Platelet-Activating Factor Receptor Antagonist Arch Ophthalmol, January 1, 2006; 124(1): 70 - 78. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Sang, J. Zhang, V. Marcheselli, N. G. Bazan, and C. Chen Postsynaptically Synthesized Prostaglandin E2 (PGE2) Modulates Hippocampal Synaptic Transmission via a Presynaptic PGE2 EP2 Receptor J. Neurosci., October 26, 2005; 25(43): 9858 - 9870. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Heinbockel, D. H. Brager, C. G. Reich, J. Zhao, S. Muralidharan, B. E. Alger, and J. P. Y. Kao Endocannabinoid Signaling Dynamics Probed with Optical Tools J. Neurosci., October 12, 2005; 25(41): 9449 - 9459. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Esquenazi, H. E. P. Bazan, V. Bui, J. He, D. B. Kim, and N. G. Bazan Topical Combination of NGF and DHA Increases Rabbit Corneal Nerve Regeneration after Photorefractive Keratectomy Invest. Ophthalmol. Vis. Sci., September 1, 2005; 46(9): 3121 - 3127. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Pifferi, F. Roux, B. Langelier, J.-M. Alessandri, S. Vancassel, M. Jouin, M. Lavialle, and P. Guesnet (n-3) Polyunsaturated Fatty Acid Deficiency Reduces the Expression of Both Isoforms of the Brain Glucose Transporter GLUT1 in Rats J. Nutr., September 1, 2005; 135(9): 2241 - 2246. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Wang, I. M. Hitron, C. Iadecola, and V. M. Pickel Synaptic and Vascular Associations of Neurons Containing Cyclooxygenase-2 and Nitric Oxide Synthase in Rat Somatosensory Cortex Cereb Cortex, August 1, 2005; 15(8): 1250 - 1260. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Aid, S. Vancassel, A. Linard, M. Lavialle, and P. Guesnet Dietary Docosahexaenoic Acid [22: 6(n-3)] as a Phospholipid or a Triglyceride Enhances the Potassium Chloride-Evoked Release of Acetylcholine in Rat Hippocampus J. Nutr., May 1, 2005; 135(5): 1008 - 1013. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Belayev, V. L. Marcheselli, L. Khoutorova, E. B. Rodriguez de Turco, R. Busto, M. D. Ginsberg, and N. G. Bazan Docosahexaenoic Acid Complexed to Albumin Elicits High-Grade Ischemic Neuroprotection Stroke, January 1, 2005; 36(1): 118 - 123. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kitajka, A. J. Sinclair, R. S. Weisinger, H. S. Weisinger, M. Mathai, A. P. Jayasooriya, J. E. Halver, and L. G. Puskas Effects of dietary omega-3 polyunsaturated fatty acids on brain gene expression PNAS, July 27, 2004; 101(30): 10931 - 10936. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Marszalek, C. Kitidis, A. Dararutana, and H. F. Lodish Acyl-CoA Synthetase 2 Overexpression Enhances Fatty Acid Internalization and Neurite Outgrowth J. Biol. Chem., June 4, 2004; 279(23): 23882 - 23891. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| All ASBMB Journals | Journal of Biological Chemistry |
| Molecular and Cellular Proteomics | ASBMB Today |