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A more recent version of this article appeared on October 1, 2004

Papers In Press, published online ahead of print August 1, 2004
J. Lipid Res., doi:10.1194/jlr.R400006-JLR200
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Submitted on July 16, 2004
Revised on July 27, 2004
Accepted on July 29, 2004

Toward a biological network for atherosclerosis

Anatole Ghazalpour, Sudheer Doss, Xia Yang, Jason Aten, Edward M. Toomey, Atila Van Nas, Susanna Wang, Thomas A. Drake, and Aldons J. Lusis

Department of Medicine, Universityof California Los Angeles, Los Angeles, CA 90095-1679

Corresponding Author: jlusis{at}mednet.ucla.edu

The goal of systems biology is to define all of the elements present in a given system, and to create an interaction network between these components so that the behavior of the system, as a whole and in parts, can be explained under specified conditions. The elements constituting the network influencing the development of atherosclerosis could be genes, pathways, transcript levels, proteins, or physiologic traits. In this review, we discuss how the integration of genetics and technologies such as transcriptomics and proteomics, combined with mathematical modeling, may lead to an understanding of such networks..


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