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Papers In Press, published online ahead of print July 1, 2005
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Medicine Dept., University of California San Diego, La Jolla, CA 92093-0682
Corresponding Author: dsteinberg{at}ucsd.edu
In this third installment of the series, we point out that the absence of an explicit, detailed and plausible hypothesis linking hypercholesterolemia to the events in the artery wall was probably an important reason for continuing skepticism and for failure to treat elevated blood cholesterol levels. The rapid advances in understanding of lipoprotein metabolism in the 50s and 60s and the application of modern cellular biology in the 70s provided the context for a modern consensus on pathogenetic mechanisms of atherogenesis.
Accepted on June 28, 2005
Thematic review series: The Pathogenesis of Atherosclerosis. An interpretive history of the cholesterol controversy, part III: mechanistically defining the role of hyperlipidemia in the pathogenesis
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