Submitted on July 6, 2006
Accepted on July 11, 2006
Approaches to lipid metabolism gene identification and characterization in the post-genomic era
Karen Reue and Laurent Vergnes
Human Genetics, University of California, Los Angeles, CA 90095
Corresponding Author: reuek{at}ucla.edu
The availability of genomic resources, such as whole genome sequence from several mammalian species and high throughput functional genomics projects, has already had a tremendous impact on biomedical research. In this review, we describe how these resources have facilitated the identification and characterization of important genes in lipid metabolism and disease. We describe key approaches that have led to gene discovery in the lipid field in the first years of this century, and discuss how such approaches are likely to streamline gene identification and functional characterization in the future.
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