J. Lipid Res.
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A more recent version of this article appeared on October 1, 2007 Originally published In Press as doi:10.1194/jlr.R700009-JLR200 on May 11, 2007

Papers In Press, published online ahead of print May 16, 2007
J. Lipid Res., doi:10.1194/jlr.R700009-JLR200
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Submitted on May 1, 2007
Revised on May 10, 2007
Accepted on May 10, 2007

Cellular spelunking: exploring adipocyte caveolae

Paul F. Pilch, Ricardo P. Souto, Libin Liu, Mark P. Jedrychowski, Eric A. Berg, Catherine E. Costello, and Steven P. Gygi

Biochemistry, Boston University School of Medicine, Boston, MA 02118

Corresponding Author: ppilch{at}bu.edu

It has been known for decades that the adipocyte cell surface is particularly rich in small invaginations we now know to be caveolae. These structures are common to many cell types but are not ubiquitous. They have generated considerable curiosity as manifested by the numerous publications on the topic that describe various, sometimes contradictory caveolae functions. Here we review the field from an “adipocentric” point of view and suggest that caveolae may have a function of particular use for the fat cell, namely modulation of fatty acid flux across the plasma membrane. Other functions for adipocyte caveolae that have been postulated include participation in signal transduction and membrane trafficking pathways and it will require further experimental scrutiny to resolve controversies surrounding these possible activities.


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L. Liu and P. F. Pilch
A Critical Role of Cavin (Polymerase I and Transcript Release Factor) in Caveolae Formation and Organization
J. Biol. Chem., February 15, 2008; 283(7): 4314 - 4322.
[Abstract] [Full Text] [PDF]


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