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J. Lipid Res.
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A more recent version of this article appeared on April 1, 2009

Papers In Press, published online ahead of print September 24, 2008
J. Lipid Res., doi:10.1194/jlr.R800026-JLR200
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Submitted on September 22, 2008
Revised on September 24, 2008
Accepted on September 24, 2008

50 years of advances in bile acid synthesis and metabolism

David W. Russell

Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046

Corresponding Author: david.russell{at}utsouthwestern.edu

There are two major pathways that mammalian cells use to supply themselves with cholesterol, one involving the synthesis of sterols from acetyl-CoA and the other the metabolism of cholesterol-rich lipoprotein particles via receptor-mediated endocytosis. There also are several pathways that mammalian cells use to break down cholesterol and these disposal pathways are equal in physiological importance to the supply pathways. A major catabolic route involves conversion of cholesterol into conjugated bile salts, a transformation mediated by 16 or more liver enzymes. This review highlights findings in cholesterol catabolism from the last five decades with special emphasis on advances in bile acid synthesis, transport, and regulation.


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JLR 50th Anniversary Collections
Anniversary Collection:: Metabolism

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