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Papers In Press, published online ahead of print October 27, 2008 J. Lipid Res., doi:10.1194/jlr.R800036-JLR200
Med- Cardiol, UCLA, Los Angeles, CA 90095
Corresponding Author: mnavab{at}mednet.ucla.edu
This review focuses on HDL function in modulating LDL oxidation and LDL-induced inflammation. Dysfunctional HDL has been identified in animal models and humans with chronic inflammatory diseases including atherosclerosis. The loss of anti-inflammatory function correlated with a loss of function in reverse cholesterol transport. In animal models and perhaps in humans, dysfunctional HDL can be improved by apoA-I mimetic peptides that bind oxidized lipids with high affinity.
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