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J. Lipid Res.
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A more recent version of this article appeared on April 1, 2009

Papers In Press, published online ahead of print December 1, 2008
J. Lipid Res., doi:10.1194/jlr.R800079-JLR200
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Submitted on November 7, 2008
Revised on November 24, 2008
Accepted on November 30, 2008

Fatty acid metabolism: target for metabolic syndrome

Salih J. Wakil and Lutfi A. Abu-Elheiga

Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030

Corresponding Author: swakil{at}bcm.tmc.edu

Fatty acids are a major energy source and important constituents of membrane lipids, and they serve as cellular signaling molecules that play an important role in the etiology of the metabolic syndrome. Acetyl-coenzyme A carboxylases 1 and 2 (ACC1 and ACC2) catalyze the synthesis of malonyl-CoA, the substrate for fatty acid synthesis and the regulator of fatty acid oxidation. They are highly regulated and play important roles in the energy metabolism of fatty acids in animals, including humans. They are presently considered as an attractive target to regulate the human diseases of obesity, diabetes, cancer, and cardiovascular complications. In this review we discuss the role of fatty acid metabolism and its key players ACC1 and ACC2 in animal evolution and physiology, as related to health and disease.


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JLR 50th Anniversary Collections
Anniversary Collection:: Metabolism

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