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J. Lipid Res.
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A more recent version of this article appeared on October 1, 2009

Papers In Press, published online ahead of print July 16, 2009
J. Lipid Res., doi:10.1194/jlr.R900015-JLR200
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Submitted on May 19, 2009
Revised on July 16, 2009
Accepted on July 16, 2009

Lipoproteomics: using mass spectrometry-based proteomics to explore the assembly, structures, and functions of lipoproteins

Andy F. Hoofnagle and Jay W. Heinecke

Laboratory Medicine, University of Washington Medical Center, Seattle, WA 98195-7110

Corresponding Author: ahoof{at}washington.edu

Lipoproteins are centrally important in lipid transport, fuel metabolism, and cardiovascular disease. The prototypic lipoprotein has an outer shell of amphipathic lipids and proteins that solubilizes a hydrophobic lipid core. Lipoprotein-associated proteins have classically been viewed as structural elements and factors important in lipid metabolism. Recent mass spectrometric analyses reveal that the protein cargo of lipoproteins is much more diverse than previously appreciated, raising the possibility that lipoproteins play previously unsuspected roles in host defense mechanisms and inflammation. They further suggest that lipoprotein-associated proteins can identify humans at increased risk of cardiovascular disease. Here, we summarize recent developments in lipoproteomics—the proteomic analysis of lipoproteins. We also discuss the promises and challenges this powerful analytical strategy offers for expanding our understanding of the biology and structures of lipoproteins.


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 Physiol. GenomicsHome page
L. A. Collins, S. P. Mirza, A. H. Kissebah, and M. Olivier
Integrated approach for the comprehensive characterization of lipoproteins from human plasma using FPLC and nano-HPLC-tandem mass spectrometry
Physiol Genomics, February 1, 2010; 40(3): 208 - 215.
[Abstract] [Full Text] [PDF]


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