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The figure shows a hematoxylin and eosin-stanined section of the duodenum of a mouse that was homozygous for an apoB knockout mutation and meizygous for a human apoB transgene. The vacuolization in the absorptive enterocytes represents cytosolic fat, which accumulated as a result of an inability of these cells to synthesize apoB and secrete chylomicrons. The human apoB transgene lacked the distant DNA sequences responsible for apoB gene expression in the intestine. Thus, this mouse could not synthesize any apoB, mouse or human, in the intestine. (See Kim and Young, p. 703.)
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Copyright © 2003 by Lipid Research, Inc.
