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Physical cholesterol domains develop in the plasma membranes of arterial smooth muscle cells during the early development of atherosclerotic lesions in cholesterol-fed rabbits. Prior to their formation, the membrane bilayer thickness increases until a saturating concentration of cholesterol in the membrane is exceeded, at which point the cholesterol phase separates, forming tail-to-tail cholesterol "bilayers" in the plane of the cell membrane. (Figure courtesy of M. Tresini.) (See Tulenko et al., p. 947.)
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