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Model of factors involved in the regulation of HDL-C levels. Plus and minus signs represent positive and inverse correlations, respectively; question mark refers to a speculated association. Solid-line boxes represent factors that are routine clinical measurements. Dotted-line boxes represent factors that can be measured from plasma samples, but are not routine clinical measurements. Ovals represent factors that can only be determined by turnover studies in human subjects. Triple-line boxes represent genetic information that can be ascertained from whole blood samples in a genetic laboratory; HL, hepatic lipase; TG, triglyercides. (See De Oliveira e Silva et al., p. 1211.)
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