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Model of the proposed interaction between peripheral tissue retinoic acid (RA) production and the regulation of lecithin:retinol acyltransferase (LRAT) expression and retinyl ester (RE) formation and storage in liver, mainly in stellate cells. Bottom: fluorescence microscopy of HEK293T cells transfected with LRAT cDNA (left) and HEK293T cells transfected with empty vector (right). Both cell cultures were incubated for 24 h with 2 {mu}M retinol. RBP, retinol-binding protein. (See Zolfaghari and Ross, p. 2024.)
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